Anaesthesia With Propofol Versus Midazolam : Effect on Oxidative Stress in the Brain of Head Trauma Patients
Terminated
Ministry of Health, France
Phase 3
2006-06-01
Severe traumatic brain injury is associated with an increased production of free radicals
causing brain damage. First line treatment of these patients aims to maintain cerebral
perfusion and includes deep anaesthesia. Propofol has recently shown anti oxidant properties
that need to be confirmed when used in these patients. The main objective of this study is to
evaluate the effect of propofol compared to midazolam on intra cerebral oxidative stress
following severe traumatic brain injury.
Anaesthesia With Propofol Versus Midazolam : Effect on Oxidative Stress in the Brain of Head Trauma Patients
Terminated
Rennes University Hospital
Phase 3
2006-06-01
Severe traumatic brain injury is associated with an increased production of free radicals
causing brain damage. First line treatment of these patients aims to maintain cerebral
perfusion and includes deep anaesthesia. Propofol has recently shown anti oxidant properties
that need to be confirmed when used in these patients. The main objective of this study is to
evaluate the effect of propofol compared to midazolam on intra cerebral oxidative stress
following severe traumatic brain injury.
Dexmedetomidine (Precedex, Hospira) is a "super" selective alpha2-agonist - 8-10x more avid
binding to alpha2 receptors than clonidine - and may have particularly favorable
characteristics as a continuous i.v. infusion sedative for critically ill neuroscience
patients. Its combination of anxiolysis, analgesia, without undue lethargy may make it an
ideal agent where frequent neurological examinations are important. Unclear, however, is
whether Precedex is superior to current common i.v. sedation protocols, and if there are any
undue concerns of this agent on cerebral physiology and cortical stimulation.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.
Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data.
The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free.
thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user.
Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.
Alerts Available With Subscription
Alerts are available for users with active subscriptions.
