Details for Patent: 5,504,207
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Summary for Patent: 5,504,207
Title: | Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
Abstract: | A process for the preparation of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (terazosin hydrochloride dihydrate comprises the steps of reacting 4-amino-2-chloro-6,7-dimethoxy-quinazoline with N-(2-tetrahydrofuroyl)piperazine in an anhydrous polar organic solvent in the absence of an added acid scavenger to produce anhydrous 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (Form IV) and thereafter converting the product of that step to 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine hydrochloride dihydrate. |
Inventor(s): | Mannino; Anthony (Round Lake Beach, IL), Henry; Rodger F. (Waukegan, IL), Heitmann; Wayne R. (Lindenhurst, IL), Horrom; Bruce W. (Waukegan, IL) |
Assignee: | Abbott Laboratories (Abbott Park, IL) |
Application Number: | 08/324,635 |
Patent Claim Types: see list of patent claims | Compound; Process; |
Drugs Protected by US Patent 5,504,207
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International Family Members for US Patent 5,504,207
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Brazil | 1100705 | ⤷ Try a Trial | |||
Canada | 2143971 | ⤷ Try a Trial | |||
Germany | 69500064 | ⤷ Try a Trial | |||
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