Details for Patent: 5,922,749
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| Title: | Medicaments for treating nausea and vomiting |
| Abstract: | The invention relates to the use of compounds of the general formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl-(C.sub.1-4) alkyl, C.sub.3-6 alkenyl, C.sub.3-10 alkynyl, phenyl or phenyl-C.sub.1-3 alkyl group; and one of the groups represented by R.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-6 alkenyl or phenyl-C.sub.1-3 alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group; and physiologically acceptable salts and solvates thereof, for the relief of nausea and vomiting and/or the promotion of gastric emptying and for the manufacture of a medicament for this purpose. Promotion of gastric emptying may be for the relief of gastro-intestinal disorders associated with gastric stasis or may be of advantage in radiological examination procedures. |
| Inventor(s): | Tyers; Michael Brian (Welwyn, GB), Coates; Ian Harold (Hertford, GB), Humber; David Cedric (Ealing, GB), Ewan; George Blanch (Gerrards Cross, GB), Bell; James Angus (Royston, GB) |
| Assignee: | Glaxo Group Limited (Greenford, GB) |
| Filing Date: | Aug 16, 1996 |
| Application Number: | 08/689,719 |
| Claims: | 1. A method of treatment for the relief of nausea and vomiting which comprises administering to a human or animal subject in need thereof an effective amount for treatment for the relief of nausea and vomiting of R-1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-car bazol-4-one or a physiologically acceptable salt or solvate thereof. 2. A method according to claim 1 wherein the R-1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-car bazol-4-one is in the form of its hydrochloride. 3. A method according to claim 1 wherein the R-1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-car bazol-4-one is in the form of its hydrochloride dihydrate. 4. A method according to claim 1 wherein said nausea and vomiting is induced by an anticancer drug. 5. A method according to claim 4 wherein the R-1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-car bazol-4-one is in the form of its hydrochloride dihydrate. 6. A method according to claim 4 wherein said anticancer drug is a cytostatic agent. 7. A method according to claim 6 wherein the R-1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-car bazol-4-one is in the form of its hydrochloride dihydrate. 8. A method according to claim 4 wherein said nausea and vomiting is induced by a platinum complex. 9. A method according to claim 8 wherein the R-1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-car bazol-4-one is in the form of its hydrochloride dihydrate. 10. A method according to claim 4 wherein said nausea and vomiting is induced by cisplatin. 11. A method according to claim 10 wherein the R-1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-car bazol-4-one is in the form of its hydrochloride dihydrate. 12. A method according to claim 1 wherein said nausea and vomiting is induced by an alkylating agent. 13. A method according to claim 1 wherein said nausea and vomiting is induced by cyclophosphamide. 14. A method according to claim 12 wherein the R-1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-car bazol-4-one is n the form of its hydrochloride dihydrate. 15. A method according to claim 13 wherein the R-1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-car bazol-4-one is in the form of its hydrochloride dihydrate. 16. A method according to claim 1 wherein said nausea and vomiting is induced by radiation. 17. A method according to claim 16 wherein the R-1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-car bazol-4-one is in the form of its hydrochloride dihydrate. |
