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Last Updated: March 28, 2024

Details for Patent: 5,549,892


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Summary for Patent: 5,549,892
Title: Enhanced in vivo uptake of glucocerebrosidase
Abstract:A pharmaceutical composition comprising remodelled recombinant glucocerebrosidase (GCR) is described that provides a therapeutic effect at doses that are lower then those required using remodelled naturally occurring GCR. A method of treating patients with Gaucher's disease using remodelled recombinant GCR is also provided. In vivo uptake of exogenous molecules can be determined by extracting a mixture of cells from a subject, enriching the target cells in vitro, lysing the cells and determining the amount of exogenous molecules.
Inventor(s): Friedman; BethAnn (Arlington, MA), Hayes; Michael (Acton, MA)
Assignee: Genzyme Corporation (Cambridge, MA)
Application Number:08/080,855
Patent Claim Types:
see list of patent claims
Composition; Use;

Drugs Protected by US Patent 5,549,892

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
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