Details for Patent: 5,549,892
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Summary for Patent: 5,549,892
Title: | Enhanced in vivo uptake of glucocerebrosidase |
Abstract: | A pharmaceutical composition comprising remodelled recombinant glucocerebrosidase (GCR) is described that provides a therapeutic effect at doses that are lower then those required using remodelled naturally occurring GCR. A method of treating patients with Gaucher's disease using remodelled recombinant GCR is also provided. In vivo uptake of exogenous molecules can be determined by extracting a mixture of cells from a subject, enriching the target cells in vitro, lysing the cells and determining the amount of exogenous molecules. |
Inventor(s): | Friedman; BethAnn (Arlington, MA), Hayes; Michael (Acton, MA) |
Assignee: | Genzyme Corporation (Cambridge, MA) |
Application Number: | 08/080,855 |
Patent Claim Types: see list of patent claims | Composition; Use; |
Drugs Protected by US Patent 5,549,892
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International Family Members for US Patent 5,549,892
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
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Austria | 138686 | ⤷ Try a Trial | |||
Canada | 2006709 | ⤷ Try a Trial | |||
Canada | 2339888 | ⤷ Try a Trial | |||
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