Details for Patent: 5,849,700
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Summary for Patent: 5,849,700
Title: | Pharmaceutical formulation |
Abstract: | A pharmaceutical preparation comprising a growth hormone and histidine or a derivative of histidine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved preparation at ambient temperature. Crystallization of growth hormone in the presence of histidine or a derivative thereof gives rise to a higher yield of crystals having a higher purity than known methods. |
Inventor(s): | S.o slashed.rensen; Hans Holmegaard (Virum, DK), Skriver; Lars (Ved.ae butted.k, DK), Hoelgaard; Annie Rassing (Holte, DK) |
Assignee: | Novo Nordisk A/S (Bagsvaerd, DK) |
Application Number: | 08/458,385 |
Patent Claim Types: see list of patent claims | Use; Composition; Formulation; |
Drugs Protected by US Patent 5,849,700
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Foreign Priority and PCT Information for Patent: 5,849,700
International Family Members for US Patent 5,849,700
Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
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Austria | 227583 | ⤷ Try a Trial | |||
Austria | 368472 | ⤷ Try a Trial | |||
Australia | 3344693 | ⤷ Try a Trial | |||
Australia | 667503 | ⤷ Try a Trial | |||
Bulgaria | 63075 | ⤷ Try a Trial | |||
Bulgaria | 98806 | ⤷ Try a Trial | |||
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