Details for Patent: 6,166,213
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Summary for Patent: 6,166,213
Title: | Omeprazole process and compositions thereof |
Abstract: | The present invention describes an improved process for the preparation, isolation, and purification of the anti-ulcer agent omeprazole whereby the sulfide precursor pyrmetazole is reacted subsurfacely with exactly one molar equivalent of meta-chloroperoxybenzoic acid in methylene chloride or toluene solution; residual organic solvent is removed from the aqueous layer by vacuum distillation; crude product is obtained by reactive crystallization with an alkyl formate and seeding; and pure product is isolated by recrystallization in methanol-water containing aqueous NaOH by subsurface addition of aqueous acetic acid to pH 9.0, seeding, filtration, washing, and drying. Compositions of omeprazole containing no chromatographically detectable levels of residual non-alcoholic organic reaction solvent are also described. |
Inventor(s): | Anousis; Nick (Albany, GA), McManus; James W. (Albany, GA), Banks; Benjamin Newton (Albany, GA), Zhou; Lingwen (North Brunswick, NJ), Liu; Hui (Greenbrook, NJ) |
Assignee: | Merck & Co., Inc. (Rahway, NJ) |
Application Number: | 09/169,231 |
Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 6,166,213 |
Patent Claim Types: see list of patent claims | Use; Compound; Process; |
Drugs Protected by US Patent 6,166,213
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International Family Members for US Patent 6,166,213
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