Details for Patent: 7,470,506
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Summary for Patent: 7,470,506
| Title: | Fitness assay and associated methods |
| Abstract: | The present invention provides an assay for determining the biochemical fitness of a biochemical species in a mutant replicating biological entity relative to its predecessor. The present invention further provides a continuous fluorogenic assay for measuring the anti-HIV protease activity of protease inhibitor. The present invention also provides a method of administering a therapeutic compound that reduces the chances of the emergence of drug resistance in therapy. The present invention also provides a compound of formula (I) or a pharmaceutically acceptable salt, a prodrug, a composition, or an ester thereof, wherein A is a group of formulas (A), (B), (C) or (D); R.sup.1, R.sup.2, R.sup.3, R.sup.5 or R.sup.6 is H, or an optionally substituted and/or heteroatom-bearing alkyl, alkenyl, alkynyl, or cyclic group; Y and/or Z are CH.sub.2, O, S, SO, SO.sub.2, amino, amides, carbamates, ureas, or thiocarbonyl derivatives thereof, optionally substituted with an alkyl, alkenyl, or alkynyl group; n is from 1 to 5; X is a bond, an optionally substituted methylene or ethylene, an amino, O or S; Q is C(O), C(S), or SO.sub.2; m is from 0 to 6; R.sup.4 is OH, .dbd.O (keto), NH.sub.2, or alkylamino, including esters, amides, and salts thereof; and W is C(O), C(S), S(O), or SO.sub.2. Optionally, R.sup.5 and R.sup.6, together with the N--W bond of formula (I), comprises a macrocyclic ring. |
| Inventor(s): | Erickson; John W. (Frederick, MD), Gulnik; Sergei V. (Frederick, MD), Mitsuya; Hiroaki (Chevy Chase, MD), Ghosh; Arun K. (River Forest, IL) |
| Assignee: | The United States of America as represented by the Department of Health and Human Services (Washington, DC) N/A (Urbana, IL) Board of Trustees of the University of Illinois (N/A) |
| Application Number: | 09/720,276 |
| Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for patent 7,470,506 |
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Patent Claim Types: see list of patent claims | Use; |
Drugs Protected by US Patent 7,470,506
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Patented / Exclusive Use | Submissiondate |
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| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Patented / Exclusive Use | >Submissiondate |
Foreign Priority and PCT Information for Patent: 7,470,506
| PCT Information | |||
| PCT Filed | June 23, 1999 | PCT Application Number: | PCT/US99/14119 |
| PCT Publication Date: | December 29, 1999 | PCT Publication Number: | WO99/67417 |
International Family Members for US Patent 7,470,506
| Country | Patent Number | Estimated Expiration | Supplementary Protection Certificate | SPC Country | SPC Expiration |
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| Austria | 500823 | ⤷ Try a Trial | |||
| Australia | 4828099 | ⤷ Try a Trial | |||
| Australia | 4828199 | ⤷ Try a Trial | |||
| Australia | 771780 | ⤷ Try a Trial | |||
| Canada | 2336160 | ⤷ Try a Trial | |||
| Canada | 2872424 | ⤷ Try a Trial | |||
| Cyprus | 1112172 | ⤷ Try a Trial | |||
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