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Profile for Tradename: JAKAFI

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Jakafi is a drug marketed by Incyte Corp and is included in one NDA. It is available from one supplier. There are six patents protecting this drug.

This drug has eigthy-one patent family members in thirty-four countries.

The generic ingredient in JAKAFI is ruxolitinib phosphate. There is one drug master file entry for this compound. One supplier is listed for this compound. Additional details are available on the ruxolitinib phosphate profile page.

Summary for Tradename: JAKAFI

Patents:6
Applicants:1
NDAs:1
Suppliers / Packagers: see list6

Pharmacology for Tradename: JAKAFI

Drug ClassKinase Inhibitor
Mechanism of ActionProtein Kinase Inhibitors

Clinical Trials for: JAKAFI

Ruxolitinib for Chronic Myeloid Leukemia (CML) With Minimal Residual Disease (MRD)
Status: Recruiting Condition: Leukemia

Study of Ruxolitinib Plus Decitabine in Patients With Acute Myeloid Leukemia (AML)
Status: Recruiting Condition: Leukemia; Myeloproliferative Diseases

Ruxolitinib and Pracinostat Combination Therapy for Patients With Myelofibrosis (MF)
Status: Recruiting Condition: Myeloproliferative Diseases

Administration of Jakafi (Ruxolitinib) for Symptom Control of Patients With Chronic Lymphocytic Leukemia (CLL): Phase II
Status: Recruiting Condition: Leukemia

Ruxolitinib or Dasatinib With Chemotherapy in Patients With Philadelphia Chromosome (Ph)-Like Acute Lymphoblastic Leukemia (ALL)
Status: Recruiting Condition: Leukemia

Ruxolitinib for Patients With Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
Status: Recruiting Condition: Leukemia

Study of Ruxolitinib in Colorectal Cancer Patients
Status: Recruiting Condition: Metastatic Colorectal Cancer

Phase l/II Study of Ruxolitinib for Acute Leukemia
Status: Active, not recruiting Condition: Leukemia

Ruxolitinib in Combination With Autotransplant
Status: Recruiting Condition: Myelofibrosis; MF

Ruxolitinib Prior to Transplant in Patients With Myelofibrosis
Status: Recruiting Condition: Primary Myelofibrosis; Post Polycythemia Vera Myelofibrosis; Post Essential Thrombocythemia Myelofibrosis

Courtesy of ClinicalTrials.org
See more clinical trials for this drug
Applicant Tradename Generic Name Dosage NDA Approval Date Type RLD Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Incyte Corp
JAKAFI
ruxolitinib phosphate
TABLET;ORAL202192-003Nov 16, 2011RXNo9,079,912<disabled><disabled>
Incyte Corp
JAKAFI
ruxolitinib phosphate
TABLET;ORAL202192-004Nov 16, 2011RXNo<disabled><disabled>
Incyte Corp
JAKAFI
ruxolitinib phosphate
TABLET;ORAL202192-005Nov 16, 2011RXYes8,415,362<disabled>YY<disabled>
Incyte Corp
JAKAFI
ruxolitinib phosphate
TABLET;ORAL202192-004Nov 16, 2011RXNo9,079,912<disabled><disabled>
Incyte Corp
JAKAFI
ruxolitinib phosphate
TABLET;ORAL202192-004Nov 16, 2011RXNo<disabled><disabled>
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International Patent Family for Tradename: JAKAFI

Country Document Number Publication Date
EcuadorSP099802Jan 29, 2010
Dominican RepublicP2009000280Mar 31, 2010
Mexico2009013402Feb 24, 2010
Spain2373688Feb 07, 2012
South Korea20110137406Dec 22, 2011
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ISSN: 2162-2639

Preferred citation:

Friedman, Y. Location of pharmaceutical innovation: 2000–2009 Nature Reviews Drug Discovery 9, 835–836 (2010).

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