ponvory Drug Patent Profile
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Which patents cover Ponvory, and when can generic versions of Ponvory launch?
Ponvory is a drug marketed by Janssen Pharms and is included in one NDA. There are six patents protecting this drug.
This drug has one hundred and forty-three patent family members in forty countries.
The generic ingredient in PONVORY is ponesimod. One supplier is listed for this compound. Additional details are available on the ponesimod profile page.
DrugPatentWatch® Generic Entry Outlook for Ponvory
Ponvory will be eligible for patent challenges on March 18, 2025. This date may extended up to six months if a pediatric exclusivity extension is applied to the drug's patents.
By analyzing the patents and regulatory protections it appears that the earliest date
for generic entry will be May 6, 2032. This may change due to patent challenges or generic licensing.
Indicators of Generic Entry
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Summary for ponvory
International Patents: | 143 |
US Patents: | 6 |
Applicants: | 1 |
NDAs: | 1 |
Finished Product Suppliers / Packagers: | 1 |
Raw Ingredient (Bulk) Api Vendors: | 46 |
Clinical Trials: | 1 |
Patent Applications: | 72 |
Drug Prices: | Drug price information for ponvory |
What excipients (inactive ingredients) are in ponvory? | ponvory excipients list |
DailyMed Link: | ponvory at DailyMed |
![ponvory drug patent expirations Drug patent expirations by year for ponvory](/p/graph/s/t/ponvory-patent-expirations.png)
![Drug Prices for ponvory](/p/graph/drug-price/ponvory.png)
DrugPatentWatch® Estimated Loss of Exclusivity (LOE) Date for ponvory
Generic Entry Date for ponvory*:
Constraining patent/regulatory exclusivity:
NDA:
Dosage:
TABLET;ORAL |
*The generic entry opportunity date is the latter of the last compound-claiming patent and the last regulatory exclusivity protection. Many factors can influence early or later generic entry. This date is provided as a rough estimate of generic entry potential and should not be used as an independent source.
Recent Clinical Trials for ponvory
Identify potential brand extensions & 505(b)(2) entrants
Sponsor | Phase |
---|---|
Janssen Pharmaceutica N.V., Belgium | Phase 1 |
Pharmacology for ponvory
Drug Class | Sphingosine 1-phosphate Receptor Modulator |
Mechanism of Action | Sphingosine 1-Phosphate Receptor Modulators |
US Patents and Regulatory Information for ponvory
ponvory is protected by six US patents and one FDA Regulatory Exclusivity.
Based on analysis by DrugPatentWatch, the earliest date for a generic version of ponvory is ⤷ Sign Up.
This potential generic entry date is based on patent ⤷ Sign Up.
Generics may enter earlier, or later, based on new patent filings, patent extensions, patent invalidation, early generic licensing, generic entry preferences, and other factors.
Patents protecting ponvory
Dosing regimen for a selective S1P.sub.1 receptor agonist
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Patented Use: TREATMENT OF RELAPSING FORMS OF MULTIPLE SCLEROSIS (MS), TO INCLUDE CLINICALLY ISOLATED SYNDROME, RELAPSING-REMITTING DISEASE, AND ACTIVE SECONDARY PROGRESSIVE DISEASE, IN ADULTS USING A DOSE TITRATION SCHEDULE FOLLOWED BY A MAINTENANCE DOSE
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Patented Use: TREATMENT OF RELAPSING FORMS OF MULTIPLE SCLEROSIS (MS), TO INCLUDE CLINICALLY ISOLATED SYNDROME, RELAPSING-REMITTING DISEASE, AND ACTIVE SECONDARY PROGRESSIVE DISEASE, IN ADULTS BEING TREATED WITH A BETA-BLOCKER OR IN ADULTS REINITIATING TREATMENT
Thiazolidin 4-one derivatives
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Patented Use: TREATMENT OF RELAPSING FORMS OF MULTIPLE SCLEROSIS (MS), TO INCLUDE CLINICALLY ISOLATED SYNDROME, RELAPSING-REMITTING DISEASE, AND ACTIVE SECONDARY PROGRESSIVE DISEASE, IN ADULTS
Thiazolidin-4-one-derivatives
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Patented Use: REDUCTION OF CIRCULATING LYMPHOCYTES IN TREATING RELAPSING FORMS OF MULTIPLE SCLEROSIS (MS), TO INCLUDE CLINICALLY ISOLATED SYNDROME, RELAPSING-REMITTING DISEASE, AND ACTIVE SECONDARY PROGRESSIVE DISEASE, IN ADULTS
Crystalline forms of (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]-propylim- ino)-3-0-tolyl-thiazolidin-4-one
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
Patented Use: TREATMENT OF RELAPSING FORMS OF MULTIPLE SCLEROSIS (MS), TO INCLUDE CLINICALLY ISOLATED SYNDROME, RELAPSING-REMITTING DISEASE, AND ACTIVE SECONDARY PROGRESSIVE DISEASE, IN ADULTS
Thiazolidin-4-one derivatives
Patent Number: ⤷ Sign Up
Patent Expiration: ⤷ Sign Up
FDA Regulatory Exclusivity protecting ponvory
NEW CHEMICAL ENTITY
Exclusivity Expiration: ⤷ Sign Up
Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Exclusivity Expiration |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Janssen Pharms | PONVORY | ponesimod | TABLET;ORAL | 213498-006 | Mar 18, 2021 | RX | Yes | No | ⤷ Sign Up | ⤷ Sign Up | Y | Y | ⤷ Sign Up | ||
Janssen Pharms | PONVORY | ponesimod | TABLET;ORAL | 213498-005 | Mar 18, 2021 | RX | Yes | No | ⤷ Sign Up | ⤷ Sign Up | ⤷ Sign Up | ||||
Janssen Pharms | PONVORY | ponesimod | TABLET;ORAL | 213498-007 | Mar 18, 2021 | RX | Yes | No | ⤷ Sign Up | ⤷ Sign Up | ⤷ Sign Up | ||||
Janssen Pharms | PONVORY | ponesimod | TABLET;ORAL | 213498-009 | Mar 18, 2021 | RX | Yes | No | ⤷ Sign Up | ⤷ Sign Up | ⤷ Sign Up | ||||
>Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >Approval Date | >TE | >Type | >RLD | >RS | >Patent No. | >Patent Expiration | >Product | >Substance | >Delist Req. | >Exclusivity Expiration |
EU/EMA Drug Approvals for ponvory
Company | Drugname | Inn | Product Number / Indication | Status | Generic | Biosimilar | Orphan | Marketing Authorisation | Marketing Refusal |
---|---|---|---|---|---|---|---|---|---|
Janssen-Cilag International N.V. | Ponvory | ponesimod | EMEA/H/C/005163 Ponvory is indicated for the treatment of adult patients with relapsing forms of multiple sclerosis (RMS) with active disease defined by clinical or imaging features. |
Authorised | no | no | no | 2021-05-19 | |
>Company | >Drugname | >Inn | >Product Number / Indication | >Status | >Generic | >Biosimilar | >Orphan | >Marketing Authorisation | >Marketing Refusal |
International Patents for ponvory
When does loss-of-exclusivity occur for ponvory?
Based on analysis by DrugPatentWatch, the following patents block generic entry in the countries listed below:
Argentina
Patent: 3904
Patent: FORMAS CRISTALINAS DE DERIVADOS DE TIAZOLIDINONA UTILES COMO INMUNOMODULADORES
Estimated Expiration: ⤷ Sign Up
Australia
Patent: 09305980
Patent: Crystalline forms of (R) -5- [3-chloro-4- ( 2, 3-dihydroxy-propoxy) -benz [Z] ylidene] -2- ( [Z] -propylimino) -3-0-tolyl-thiazolidin-4-one
Estimated Expiration: ⤷ Sign Up
Brazil
Patent: 0919673
Patent: formas cristalinas de (r)-5-[3-cloro-4-(2,3-diidróxi-propoxi)-benz[z]ilideno]-2-([z]-propilimino)-3-o-tolila-tiazolidin-4-ona
Estimated Expiration: ⤷ Sign Up
Canada
Patent: 40313
Patent: FORMES CRISTALLINES DE LA (R)-5[3-CHLORO-4-(2,3-DIHYDROXY-PROPOXY)-BENZ-[Z]-YLIDENE]-2-([Z]-PROPYLIMINO)-3-O-TOLYL-THIAZOLIDIN-4-ONE (CRYSTALLINE FORMS OF (R) -5- [3-CHLORO-4- ( 2, 3-DIHYDROXY-PROPOXY) -BENZ [Z] YLIDENE] -2- ( [Z] -PROPYLIMINO) -3-0-TOLYL-THIAZOLIDIN-4-ONE)
Estimated Expiration: ⤷ Sign Up
Chile
Patent: 11000867
Patent: Formas cristalinas da, c y ii de (r)-5-[3-cloro-4-(2,3-dihidroxi-propoxi)- benz[z]ilideno]-2- ([z]- propilimino) -3-o- totil-tiazolidin-4-ona; composicion farmaceutica; y uso en el tratamiento o prevencion de rechazo de organos trasplantados, sindrome autoinmunitarios, asma, diabetes, cancer.
Estimated Expiration: ⤷ Sign Up
China
Patent: 2177144
Patent: Crystalline forms of (R) -5- [3-chloro-4- ( 2, 3-dihydroxy-propoxy) -benz [Z] ylidene] -2- ( [Z] -propylimino) -3-0-tolyl-thiazolidin-4-one
Estimated Expiration: ⤷ Sign Up
Croatia
Patent: 0150391
Estimated Expiration: ⤷ Sign Up
Cyprus
Patent: 16118
Estimated Expiration: ⤷ Sign Up
Denmark
Patent: 44465
Estimated Expiration: ⤷ Sign Up
European Patent Office
Patent: 44465
Patent: FORMES CRISTALLINES DE LA (R)-5[3-CHLORO-4-(2,3-DIHYDROXY-PROPOXY)-BENZ-[Z]-YLIDÈNE]-2-([Z]-PROPYLIMINO)-3-O-TOLYL-THIAZOLIDIN-4-ONE (CRYSTALLINE FORMS OF (R) -5- [3-CHLORO-4-( 2, 3-DIHYDROXY-PROPOXY)-BENZ [Z]YLIDENE]-2- [Z]-PROPYLIMINO) -3-O-TOLYL-THIAZOLIDIN-4-ONE)
Estimated Expiration: ⤷ Sign Up
Hong Kong
Patent: 59624
Estimated Expiration: ⤷ Sign Up
Israel
Patent: 2351
Patent: צורות גבישיות שאינן היגרוסקופיות של (r)-5-[3-כלורו-4-(3,2-דיהידרוקסי-פרופוקסי)-בנז [z]ילאידן]-2-([z]-פרופילאימינו)-3-o-טוליל-תיאזולידין-4-און, המכילות בין 0 ל 0.5 אקוויולנט מים לאקוויוולנט מולקולה, תכשירי רוקחות ושימושים שלהן (Non-hygroscopic crystalline forms of (r)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[z]ylidene]-2-([z]-propylimino)-3-o-tolyl-thiazolidin-4-one, containing from 0 to 0.5 equivalents of water per equivalent of compound, pharmaceutical compositions and uses thereof)
Estimated Expiration: ⤷ Sign Up
Japan
Patent: 08777
Estimated Expiration: ⤷ Sign Up
Patent: 12505873
Estimated Expiration: ⤷ Sign Up
Malaysia
Patent: 0703
Patent: CRYSTALLINE FORMS OF (R) -5- [3-CHLORO-4-(2,3-DIHYDROXY) - BENZ [Z] YLIDENE] -2- ([Z]-PROPYLIMINO) -3-0-TOLYL-THIAZOLIDIN-4-ONE
Estimated Expiration: ⤷ Sign Up
Mexico
Patent: 11003988
Patent: FORMAS CRISTALINAS DE (R)-5-[3-CLORO-4-(2,3-DIHIDROXI-PROPOXI)-BEN Z[Z]ILIDENO]-2-([Z]-PROPILIMINO)-3-O-TOLIL-TIAZOLIDIN-4-ONA. (CRYSTALLINE FORMS OF (R) -5- [3-CHLORO-4- ( 2, 3-DIHYDROXY-PROPOXY) -BENZ [Z] YLIDENE] -2- ( [Z] -PROPYLIMINO) -3-0-TOLYL-THIAZOLIDIN-4-ONE.)
Estimated Expiration: ⤷ Sign Up
Morocco
Patent: 797
Patent: أشكال البلورية (r) -5 [3 كلورو-4- (2،3-ثنائي هيدروكسي بروبوكسي) بنز [z]-إيليدين] -2 - ([z]-بروبيليمينو)-3-o -طوليل-تيازولين-4-أون
Estimated Expiration: ⤷ Sign Up
New Zealand
Patent: 2854
Patent: CRYSTALLINE FORMS OF (R)-5-[3-CHLORO-4-(2,3-DIHYDROXY-PROPOXY)-BENZ[Z]YLIDENE]-2-([Z]-PROPYLIMINO)-3-O-TOLYL-THIAZOLIDIN-4-ONE
Estimated Expiration: ⤷ Sign Up
Poland
Patent: 44465
Estimated Expiration: ⤷ Sign Up
Portugal
Patent: 44465
Estimated Expiration: ⤷ Sign Up
Russian Federation
Patent: 19548
Patent: КРИСТАЛЛИЧЕСКИЕ ФОРМЫ (R)-5-[3-ХЛОР-4-(2, 3-ДИГИДРОКСИПРОПОКСИ)БЕНЗ[Z]ИЛИДЕН]-2-([Z]-ПРОПИЛИМИНО)-3-о-ТОЛИЛТИАЗОЛИДИН-4-ОНА (CRYSTALLINE FORMS OF (R)-5-[3-CHLORO-4-(2, 3-DIHYDROXYPROPOXY)BEZ[Z]ILIDEN]-2-([Z]-PROPYLIMINO)-3-o-TOLYLTHIAZOLIDIN-4-ONE)
Estimated Expiration: ⤷ Sign Up
Patent: 11119898
Patent: КРИСТАЛЛИЧЕСКИЕ ФОРМЫ (R)-5-[3-ХЛОР-4-(2,3-ДИГИДРОКСИПРОПОКСИ)БЕНЗ[Z]ИЛИДЕН]-2-([Z]-ПРОПИЛИМИНО)-3-О-ТОЛИЛТИАЗОЛИДИН-4-ОНА
Estimated Expiration: ⤷ Sign Up
Slovenia
Patent: 44465
Estimated Expiration: ⤷ Sign Up
South Africa
Patent: 1103691
Patent: CRYSTALLINE FORMS OF (R)-5-[3-CHLORO-4-(2,3-DIHYDROXY-PROPOXY)-BENZ[Z]YLIDENE]-2-([Z]-PROPYLIMINO)-3-0-TOLYL-THIAZOLIDIN-4-ONE
Estimated Expiration: ⤷ Sign Up
South Korea
Patent: 1409597
Estimated Expiration: ⤷ Sign Up
Patent: 110071133
Patent: CRYSTALLINE FORMS OF (R)-5-[3-CHLORO-4-(2,3-DIHYDROXY-PROPOXY)-BENZ[Z]YLIDENE]-2-([Z]-PROPYLIMINO)-3-0-TOLYL-THIAZOLIDIN-4-ONE
Estimated Expiration: ⤷ Sign Up
Spain
Patent: 34333
Estimated Expiration: ⤷ Sign Up
Taiwan
Patent: 62911
Estimated Expiration: ⤷ Sign Up
Patent: 1022220
Patent: Crystalline forms
Estimated Expiration: ⤷ Sign Up
United Kingdom
Patent: 19182
Estimated Expiration: ⤷ Sign Up
Generics may enter earlier, or later, based on new patent filings, patent extensions, patent invalidation, early generic licensing, generic entry preferences, and other factors.
See the table below for additional patents covering ponvory around the world.
Country | Patent Number | Title | Estimated Expiration |
---|---|---|---|
Japan | 6846392 | ⤷ Sign Up | |
China | 106999461 | 选择性S1P1受体激动剂的给药方案 (Dosing regimen for selective S1P1 receptor agonist) | ⤷ Sign Up |
South Korea | 20060117328 | 5-(BENZ-(Z)-YLIDENE)-THIAZOLIDIN-4-ONE DERIVATIVES AS IMMUNOSUPPRESSANT AGENTS | ⤷ Sign Up |
South Korea | 20210126792 | 선택적 S1P1 수용체 효능제에 대한 투약 섭생 (S1P1 DOSING REGIMEN FOR A SELECTIVE S1P1 RECEPTOR AGONIST) | ⤷ Sign Up |
>Country | >Patent Number | >Title | >Estimated Expiration |
Supplementary Protection Certificates for ponvory
Patent Number | Supplementary Protection Certificate | SPC Country | SPC Expiration | SPC Description |
---|---|---|---|---|
3256125 | PA2022505 | Lithuania | ⤷ Sign Up | PRODUCT NAME: PONEZIMODAS; REGISTRATION NO/DATE: EU/1/21/1550 20210519 |
3256125 | 18/2022 | Austria | ⤷ Sign Up | PRODUCT NAME: PONESIMOD; REGISTRATION NO/DATE: EU/1/21/1550 (MITTEILUNG) 20210521 |
3256125 | 2290019-5 | Sweden | ⤷ Sign Up | PRODUCT NAME: PONESIMOD AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF; NAT. REG. NO/DATE: EU/1/21/1550 20210521; FIRST REG.: GE EU/1/21/1550 20210521 |
3256125 | LUC00262 | Luxembourg | ⤷ Sign Up | PRODUCT NAME: PONESIMOD (NOM IUPAC : (R)-5-(3-CHLORO-4-(2,3-DIHYDROXY-PROPOXY)-BENZ(Z)YLIDENE)-2-((Z)-PROPYLIMINO)-3-O-TOLYL-THIAZOLIDIN-4-ONE); AUTHORISATION NUMBER AND DATE: EU/1/21/1550 20210521 |
>Patent Number | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration | >SPC Description |