A Study to Assess the Pharmacokinetic Comparability of Guselkumab (CNTO1959) When Delivered by 2 Different Devices and as 2 Formulations in Healthy Participants
Completed
Janssen Research & Development, LLC
Phase 1
2013-05-09
The purpose of this study is to evaluate the pharmacokinetic (what the body does to the
medication) comparability of guselkumab in lyophilized and liquid formulations. Also to
evaluate pharmacokinetic comparability of liquid formulation of guselkumab when delivered as
prefilled syringe with UltraSafe Passive Delivery System [PFS-U] or with a prefilled syringe
facilitated injection device [PFS FID]) following a single subcutaneous (SC) administration
of 100 mg guselkumab in healthy participants.
An Exploratory Genetic Study in Participants With Psoriasis
Completed
Janssen Research & Development, LLC
2014-03-01
The purpose of this study is to evaluate the association between genetic factors and response
to treatment (guselkumab, ustekinumab, adalimumab, or etanercept) and psoriasis (scaly skin
rash).
A Study of Guselkumab in Participants With Moderate to Severe Plaque-type Psoriasis and an Inadequate Response to Ustekinumab
Completed
Janssen Research & Development, LLC
Phase 3
2014-10-07
The purpose of this study is to evaluate the efficacy and safety of guselkumab (CNTO 1959) in
the treatment of participants with moderate to severe plaque-type psoriasis (scaly skin rash)
who had inadequate response to ustekinumab.
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