National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Phase 2
1999-07-01
Rheumatoid arthritis (RA) is an autoimmune disease characterized by swelling and inflammation
of the joints. In RA, the immune system attacks a person's own cells inside joints,
eventually leading to joint damage and disability. This study will determine if oral bovine
type II collagen (bovine CII) will lead to decreased joint inflammation in RA patients.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by swelling and inflammation
of the joints. In RA, the immune system attacks a person's own cells inside joints,
eventually leading to joint damage and disability. This study will determine if oral bovine
type II collagen (bovine CII) will lead to decreased joint inflammation in RA patients.
An Open Trial Combining Zidovudine, Interferon-alfa, and Recombinant CD4-IgG With Transplantation of Syngeneic Bone Marrow and Peripheral Blood Lymphocytes From Healthy gp160-Immunized Donors in the Treatment of Patients With HIV Infection
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
N/A
1969-12-31
To restore immunologic function and virus-free state in HIV-infected patients. Based on
previous studies showing temporary improvement in immune function in HIV-infected patients
using peripheral lymphocyte transfers and bone marrow transplantation, and based on studies
documenting the antiretroviral effects of zidovudine (AZT) and interferon-alfa (IFN-A) as
well as the preliminary test tube and patient studies suggesting anti-HIV effects of
recombinant CD4-IgG, we propose to treat HIV-infected patients using combination
antiretroviral therapy with transplantation of bone marrow and peripheral lymphocytes from
previously immunized donors in an attempt to restore immunologic function and a virus-free
state.
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