Claims for Patent: 5,395,760
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Summary for Patent: 5,395,760
Title: | DNA encoding tumor necrosis factor-.alpha. and -.beta. receptors |
Abstract: | Tumor necrosis factor receptor proteins, DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed. |
Inventor(s): | Smith; Craig A. (Seattle, WA), Goodwin; Raymond G. (Seattle, WA), Beckmann; M. Patricia (Poulsbo, WA) |
Assignee: | Immunex Corporation (Seattle, WA) |
Application Number: | 07/523,635 |
Patent Claims: | 1. An isolated DNA sequence consisting of a DNA sequence encoding only the amino acid sequence selected from the group consisting of amino acids 1-235 of FIG. 2A and amino acids 1-233
of FIG. 3A.
2. An isolated DNA sequence according to claim 1 which encodes a soluble human TNF-R. 3. An isolated DNA sequence consisting of a DNA sequence encoding only the amino acid sequence selected from the group consisting of amino acids 1 through x of FIG. 2A, wherein x is amino acid 163-235 of FIG. 2A. 4. An isolated DNA sequence according to claim 1 which encodes a soluble human TNF-R comprising the sequence of amino acids 1-235 of FIG. 2A. 5. An isolated DNA sequence according to claim 1 which encodes a soluble human TNF-R comprising the sequence of amino acids 1-185 of FIG. 2A. 6. An isolated DNA sequence consisting of a DNA sequence encoding only the amino acid sequence 1-163 of FIG. 2A. 7. An isolated DNA sequence according to claim 1 encoding the TNF-R polypeptide expressed by pCAV/NOT-TNF-R (ATCC 68088). 8. A recombinant expression vector comprising a DNA sequence according to claim 1. 9. A recombinant expression vector comprising a DNA sequence according to claim 2. 10. A recombinant expression vector comprising a DNA sequence according to claim 3. 11. A recombinant expression vector comprising a DNA sequence according to claim 4. 12. A recombinant expression vector comprising a DNA sequence according to claim 5. 13. A recombinant expression vector comprising a DNA sequence according to claim 6. 14. A recombinant expression vector comprising a DNA sequence according to claim 7. 15. A host cell transformed or transfected with the vector according to claim 9. 16. A host cell transformed or transfected with the vector according to claim 10. 17. A host cell transformed or transfected with the vector according to claim 11. 18. A host cell transformed or transfected with the vector according to claim 12. 19. A host cell transformed or transfected with the vector according to claim 13. 20. A host cell transformed or transfected with the vector according to claim 14. |
Details for Patent 5,395,760
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Immunex Corporation | ENBREL | etanercept | For Injection | 103795 | November 02, 1998 | 5,395,760 | 2012-03-07 |
Immunex Corporation | ENBREL | etanercept | For Injection | 103795 | May 27, 1999 | 5,395,760 | 2012-03-07 |
Immunex Corporation | ENBREL | etanercept | Injection | 103795 | September 27, 2004 | 5,395,760 | 2012-03-07 |
Immunex Corporation | ENBREL | etanercept | Injection | 103795 | February 01, 2007 | 5,395,760 | 2012-03-07 |
Immunex Corporation | ENBREL MINI | etanercept | Injection | 103795 | September 14, 2017 | 5,395,760 | 2012-03-07 |
Immunex Corporation | ENBREL | etanercept | Injection | 103795 | 5,395,760 | 2012-03-07 | |
Immunex Corporation | ENBREL | etanercept | Injection | 103795 | March 05, 2020 | 5,395,760 | 2012-03-07 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 5,395,760
Country | Patent Number | Estimated Expiration |
---|---|---|
South Africa | 907072 | ⤷ Subscribe |
World Intellectual Property Organization (WIPO) | 9406476 | ⤷ Subscribe |
World Intellectual Property Organization (WIPO) | 9319777 | ⤷ Subscribe |
World Intellectual Property Organization (WIPO) | 9103553 | ⤷ Subscribe |
United States of America | RE36755 | ⤷ Subscribe |
United States of America | 7459528 | ⤷ Subscribe |
United States of America | 7057022 | ⤷ Subscribe |
>Country | >Patent Number | >Estimated Expiration |
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