Claims for Patent: 5,605,690
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Summary for Patent: 5,605,690
Title: | Methods of lowering active TNF-.alpha. levels in mammals using tumor necrosis factor receptor |
Abstract: | A method for treating TNF-dependent inflammatory diseases in a mammal by administering a TNF antagonist, such as soluble TNFR. |
Inventor(s): | Jacobs; Cindy A. (Seattle, WA), Smith; Craig A. (Seattle, WA) |
Assignee: | Immunex Corporation (Seattle, WA) |
Application Number: | 08/385,229 |
Patent Claims: | 1. A method for lowering the levels of active TNF-.alpha. in a mammal in need thereof which comprises administering to said mammal a TNF-lowering amount of a TNF antagonist selected
from the group consisting of:
(a) a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1; and (b) a chimeric antibody comprising a TNF receptor according to (a) fused to the constant domain of an immunoglobulin molecule. 2. A method for lowering the levels of active TNF-.alpha. in a mammal in need thereof which comprises administering to said mammal a TNF-lowering amount of a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1. 3. A method for lowering the levels of active TNF-.alpha. in a mammal in need thereof which comprises administering to said mammal a TNF-lowering amount of a chimeric antibody comprising a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1 fused to the constant domain of an immunoglobulin molecule. 4. A method for lowering the levels of active TNF-.alpha. in a mammal having arthritis, which comprises administering to such mammal a therapeutically effective amount of a TNF-antagonist selected from the group consisting of: (a) a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1; and (b) a chimeric antibody comprising a TNF receptor according to (a) fused to the constant domain of an immunogloblin molecule. 5. A method for lowering the levels of active TNF-.alpha. in a mammal having arthritis, which comprises administering to said mammal a TNF-lowering amount of a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1. 6. A method for lowering the levels of active TNF-.alpha. in a mammal having arthritis, which comprises administering to said mammal a TNF-lowering amount of a chimeric antibody comprising a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1 fused to the constant domain of an immunoglobulin molecule. |
Details for Patent 5,605,690
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Immunex Corporation | ENBREL | etanercept | For Injection | 103795 | November 02, 1998 | ⤷ Sign Up | 2014-02-25 |
Immunex Corporation | ENBREL | etanercept | For Injection | 103795 | May 27, 1999 | ⤷ Sign Up | 2014-02-25 |
Immunex Corporation | ENBREL | etanercept | Injection | 103795 | September 27, 2004 | ⤷ Sign Up | 2014-02-25 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 5,605,690
Country | Patent Number | Estimated Expiration |
---|---|---|
South Africa | 907072 | ⤷ Sign Up |
World Intellectual Property Organization (WIPO) | 9406476 | ⤷ Sign Up |
World Intellectual Property Organization (WIPO) | 9319777 | ⤷ Sign Up |
>Country | >Patent Number | >Estimated Expiration |
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