Patent: 10,005,783

Summary for Patent: 10,005,783

Title:	Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
Abstract:	Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
Inventor(s):	Haas; Julia (Boulder, CO), Andrews; Steven W. (Boulder, CO), Jiang; Yutong (Boulder, CO), Zhang; Gan (Boulder, CO)
Assignee:	Array BioPharma Inc. (Boulder, CO)
Application Number:	15/399,389
Patent Claims:	see list of patent claims

Understanding the Scope and Claims of United States Patent 10,005,783

Introduction

United States Patent 10,005,783, titled "Method of treatment using substituted pyrazolo[1,5-a]pyrimidine compounds," is a patent that delves into the synthesis and application of specific chemical compounds for therapeutic purposes. This analysis will explore the patent's scope, claims, and the broader patent landscape in which it resides.

Patent Overview

The patent, assigned the number US10005783B2, was granted for methods of treatment using substituted pyrazolo[1,5-a]pyrimidine compounds. These compounds are designed to treat a variety of medical conditions, including pain, cancer, inflammation, neurodegenerative diseases, and infections such as those caused by Trypanosoma cruzi[4].

Scope of the Patent

The scope of the patent is defined by its claims, which outline the specific inventions and methods that are protected.

Therapeutic Applications

The patent covers the use of substituted pyrazolo[1,5-a]pyrimidine compounds for treating various diseases. This includes:

• Cancer: The compounds are indicated for treating different types of cancer, such as breast cancer, neuroblastoma, glioma, and thyroid neoplasm[4].
• Pain and Inflammation: These compounds are also useful for treating pain and inflammatory conditions.
• Neurodegenerative Diseases: The patent includes methods for treating neurodegenerative diseases.
• Infections: Specifically, the compounds are useful in treating infections caused by Trypanosoma cruzi[4].

Chemical Compounds

The patent describes the chemical structure and synthesis of the substituted pyrazolo[1,5-a]pyrimidine compounds. It includes detailed descriptions of the chemical groups and formulas involved, such as the presence of fluoro groups, pyrrolidin, and other specific chemical moieties[4].

Claims Analysis

The claims section of the patent is crucial as it defines the legal boundaries of the invention.

Independent Claims

Independent claims are those that stand alone and do not depend on other claims. In this patent, the independent claims focus on the specific compounds and their therapeutic uses. For example, Claim 1 might describe a compound with a particular chemical structure and its use in treating a specific disease[4].

Dependent Claims

Dependent claims build upon the independent claims and provide additional details or limitations. These claims might specify particular dosages, administration methods, or combinations with other drugs.

Patent Landscape

Understanding the broader patent landscape is essential for assessing the novelty and non-obviousness of the invention.

Prior Art

The patent cites prior art related to similar chemical compounds and their therapeutic applications. This includes references to other patents and scientific literature that describe similar compounds or methods of treatment[4].

Global Dossier and IP5 Offices

The Global Dossier service provided by the USPTO allows users to see the patent family for a specific application, including related applications filed at participating IP Offices. This can help in understanding how this patent fits into the global patent landscape and whether similar patents have been filed in other jurisdictions[1].

Common Citation Document (CCD)

The CCD application consolidates prior art citations from multiple IP offices, helping to visualize the citation data for the same invention across different offices. This tool can be useful in assessing the novelty and scope of the patent claims in a global context[1].

Metrics for Patent Scope

Research on patent scope often involves metrics such as independent claim length and independent claim count. These metrics can help in evaluating the breadth and clarity of the patent claims. For instance, narrower claims at publication are associated with a higher probability of grant and a shorter examination process[3].

Practical Implications

• Licensing and Litigation: The breadth and clarity of the patent claims can impact licensing and litigation costs. Overly broad or unclear claims can lead to increased legal disputes and higher costs for innovators[3].
• Innovation Incentives: The patent's scope and claims can influence the incentives for innovation. Clear and well-defined claims can encourage further research and development by providing a clear understanding of what is protected and what is not[3].

Key Takeaways

• Therapeutic Applications: The patent covers a range of therapeutic applications, including cancer, pain, inflammation, neurodegenerative diseases, and infections.
• Chemical Compounds: The patent describes specific chemical compounds and their synthesis.
• Claims Analysis: The claims define the legal scope of the invention, with independent claims focusing on the compounds and their uses.
• Patent Landscape: The patent fits into a broader landscape that includes prior art, global dossier, and common citation documents.
• Metrics for Patent Scope: Metrics like independent claim length and count can help evaluate the patent's scope and clarity.

FAQs

1. What is the main subject of United States Patent 10,005,783?

   • The main subject is the method of treatment using substituted pyrazolo[1,5-a]pyrimidine compounds for various medical conditions.

2. What diseases are treated by the compounds described in the patent?

   • The compounds are used to treat cancer, pain, inflammation, neurodegenerative diseases, and infections such as those caused by Trypanosoma cruzi[4].

3. How do independent and dependent claims differ in a patent?

   • Independent claims stand alone and define the invention, while dependent claims build upon the independent claims and provide additional details or limitations.

4. What is the Global Dossier service, and how is it relevant to this patent?

   • The Global Dossier service allows users to see the patent family for a specific application, including related applications filed at participating IP Offices, which helps in understanding the global patent landscape[1].

5. Why are metrics like independent claim length and count important in evaluating a patent?

   • These metrics help in evaluating the breadth and clarity of the patent claims, which can impact licensing, litigation, and innovation incentives[3].

Sources

1. USPTO - Search for patents
2. ACUS - U.S. Patent Small Claims Court
3. SSRN - Patent Claims and Patent Scope
4. Google Patents - US10005783B2
5. PubChem - PYRAZOLO [1,5-A] PYRIMIDINE COMPOUNDS SUBSTITUTED AS ...

Details for Patent 10,005,783

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	November 26, 1997	10,005,783	2028-10-22
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	September 25, 1998	10,005,783	2028-10-22
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	February 10, 2017	10,005,783	2028-10-22
Genentech, Inc.	PERJETA	pertuzumab	Injection	125409	June 08, 2012	10,005,783	2028-10-22
Genentech, Inc.	KADCYLA	ado-trastuzumab emtansine	For Injection	125427	February 22, 2013	10,005,783	2028-10-22