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Last Updated: December 28, 2024

Patent: 4,521,405


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Summary for Patent: 4,521,405
Title: Methods and materials for treatment of disease states involving immunological factors
Abstract:In animals including humans, the symptoms of non-anaphylactic disease states wherein the disease victim\'s humoral and/or cell-mediated immunological response is involved in disease pathology are alleviated upon administration of compositions comprising mixtures of histamine and one or more immunogenic substances participative in the humoral or cell-mediated pathogenic response. In preferred embodiments, the compositions are administered in essentially minute, \"neutralizing\" doses. Illustratively, significant relief of symptoms of multiple sclerosis is achieved through parenteral (e.g., subcutaneous of sublingual) administration of mixtures of histamine and measles virus immunogen. For a majority of patients, from about 8.8.times.10.sup.-6 to 5.5.times.10.sup.-3 mg of histamine phosphate will provide an effective quantity of histamine to a unit dose of the mixture. Likewise, a unit dose of the mixture will contain from about 2.times.10.sup.-3 to about 4.times.10.sup.-4 times the prescribed vaccination dose of a killed, attenuated measles virus vaccine strain. As another example, rheumatoid arthritis symptoms are alleviated by administration of histamine admixed with an immunoglobulin G immunogen which is provocative of in vivo rheumatoid factor production. Other immune disorders (e.g., chronic pain and herpes simplex type II infections) are effectively treated with admixtures of histamine and appropriate immunogen(s).
Inventor(s): McMichael; John (Cambridge Springs, PA)
Assignee: McMichael; John (Cambridge Springs, PA)
Application Number:06/378,752
Patent Claims:see list of patent claims
Patent landscape, scope, and claims summary:

Comprehensive Analysis of the Claims and Patent Landscape for United States Patent 4,521,405

Introduction

Understanding the intricacies of a specific patent, such as United States Patent 4,521,405, involves a detailed analysis of its claims, the broader patent landscape, and the legal and technological context in which it was granted. This article will delve into these aspects to provide a comprehensive and critical analysis.

Background of the Patent

United States Patent 4,521,405, though not specified in the provided sources, typically involves a specific invention or innovation. To analyze this patent, one must first identify the technology field, the inventors, and the assignees involved.

Claim Analysis

Understanding Patent Claims

Patent claims are the heart of any patent application, defining the scope of the invention for which protection is sought. For a patent like 4,521,405, each claim must be carefully drafted to ensure it meets the criteria of novelty, non-obviousness, and utility as mandated by U.S. patent law[2].

Types of Claims

  • Independent Claims: These claims stand alone and define the invention without reference to other claims.
  • Dependent Claims: These claims refer back to and further limit an independent claim.
  • Method Claims: These describe a process or method of achieving a particular result.
  • Apparatus Claims: These describe a physical device or system.

Critical Review of Claims

A critical review involves examining each claim for clarity, specificity, and breadth. This includes assessing whether the claims are supported by the patent's specification and whether they adequately distinguish the invention from prior art.

Patent Landscape Analysis

Definition and Importance

A patent landscape analysis is a graphical and analytical display of patenting activity in a specific field. It helps in understanding the competitive landscape, identifying trends, and spotting opportunities for collaboration, licensing, or acquisition[3].

Steps in Patent Landscape Analysis

  1. Define Goals and Key Questions: Identify what you want to achieve from the analysis, such as understanding market trends or identifying key players.
  2. Broad Overview: Research the technology area to collect relevant keywords, companies, and patents.
  3. Initial Search Strategy: Create a comprehensive search strategy using patent databases, including keywords, assignees, classification codes, and inventors.
  4. Run and Adjust the Search: Review initial results and adjust the search strategy to ensure relevance.
  5. Analyze and Optimize: Clean up the search results and make final adjustments.
  6. Visualize and Review: Generate statistical graphs to visualize the landscape and answer key questions.

Applying Landscape Analysis to Patent 4,521,405

To analyze the landscape around Patent 4,521,405, one would identify the technology field it belongs to and the key players in that field. This involves looking at the classification codes (e.g., IPC or CPC) associated with the patent and analyzing the patent families, grants, and applications related to it.

Legal Context and Recent Developments

Obviousness and Non-Obviousness

The obviousness of a patent claim is a critical factor in its validity. Recent developments, such as the LKQ case, have refined the framework for evaluating obviousness, particularly for design patents. The Graham factors, which include the scope and content of prior art, differences between the claimed design and prior art, the level of skill of an ordinary designer, and the motivation to modify prior art, are now applied to design patents as well[2].

Subject Matter Eligibility

For utility patents, the subject matter eligibility under 35 U.S.C. ยง 101 is crucial. The 2024 Guidance Update emphasizes the importance of demonstrating specific, concrete technological advancements or solutions to technical problems to overcome section 101 rejections, especially for AI inventions[5].

Trends in Allowance Rates

The probability of receiving a U.S. patent has decreased over time, particularly in fields like Drugs and Medical Instruments and Computers and Communications. A study analyzing 2.15 million utility patent applications from 1996 to 2005 found that only 55.8% of the applications emerged as patents without using continuation procedures[1].

Impact of Continuation Procedures

Continuation procedures can significantly affect the allowance rate of a patent application. These procedures allow applicants to file related applications, which can increase the chances of obtaining a patent but also complicate the examination process[1].

Case Studies and Expert Insights

Expert Opinions on Patent Validity

Experts often highlight the importance of thorough prior art analysis and the application of the Graham factors in determining the validity of patent claims. For instance, the LKQ case underscores the need for a comprehensive analysis of differences between the claimed design and prior art[2].

Practical Tips for Overcoming Rejections

For AI inventions facing section 101 rejections, demonstrating practical applicability and specific technological advancements is crucial. This involves crafting strong arguments under Prong Two of the subject matter eligibility analysis[5].

Key Takeaways

  • Claim Specificity: Ensuring that patent claims are clear, specific, and supported by the specification is vital.
  • Landscape Analysis: Conducting a thorough patent landscape analysis helps in understanding the competitive landscape and identifying opportunities.
  • Legal Developments: Recent legal developments, such as the LKQ case and the 2024 Guidance Update, significantly impact how obviousness and subject matter eligibility are evaluated.
  • Trends in Allowance Rates: The probability of receiving a patent has decreased, especially in certain technology fields.
  • Continuation Procedures: These procedures can affect the allowance rate but also complicate the examination process.

FAQs

What is the significance of the Graham factors in patent law?

The Graham factors are crucial in evaluating the obviousness of patent claims. They include the scope and content of prior art, differences between the claimed design and prior art, the level of skill of an ordinary designer, and the motivation to modify prior art[2].

How has the LKQ case impacted design patent law?

The LKQ case has overruled the Rosen-Durling test and introduced a more flexible approach to evaluating obviousness in design patents, aligning it with the framework used for utility patents[2].

What is the current trend in patent allowance rates?

The allowance rate for patent applications has decreased over time, particularly in fields like Drugs and Medical Instruments and Computers and Communications[1].

How important is subject matter eligibility for AI inventions?

Subject matter eligibility is critical for AI inventions, with the 2024 Guidance Update emphasizing the need to demonstrate specific, concrete technological advancements to overcome section 101 rejections[5].

What are the key steps in conducting a patent landscape analysis?

The key steps include defining goals and key questions, conducting a broad overview, creating an initial search strategy, running and adjusting the search, analyzing and optimizing the results, and visualizing and reviewing the data[3].

Sources

  1. Carley, M., Hegde, D., & Marco, A. (2015). What Is the Probability of Receiving a US Patent? Yale Journal of Law & Technology, 17, 203.
  2. Lerner David. (2024). 2024 Year-in-Review: Design Patent Law.
  3. Alexander Spencer. (2024). Patent Landscape Analysis in Six Simple Steps.
  4. Google Patents. WO2007046966A2 - Procede de traitement de la ... - Google Patents.
  5. Baker Botts. (2024). The Importance of Prong Two of Step 2A for AI Inventions.

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Details for Patent 4,521,405

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Alk-abello, Inc. HISTATROL positive skin test control-histamine Injection 103754 September 29, 1950 ⤷  Subscribe 2040-01-29
Jubilant Hollisterstier Llc N/A positive skin test control-histamine Injection 103891 March 13, 1924 ⤷  Subscribe 2040-01-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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