Patent: 4,737,462

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Summary for Patent: 4,737,462

Title:	Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-.beta.
Abstract:	A modified IFN-.beta. is provided wherein the cysteine residue at position 17 is deleted and serine is substituted therefor. DNA sequences coding for the modified protein, nucleotide primers used for the mutagenesis, appropriate cloning vectors, host organisms transformed with the vectors, methods for the production and use of the modified IFN-.beta. (IFN-.beta..sub.ser17) are also provided. The specific activity of IFN-.beta..sub.ser17 is found to be substantially the same as that of native IFN-.beta..
Inventor(s):	Mark; David F. (Hercules, CA), Lin; Leo S. (Fremont, CA), Yu Lu; Shi-Da (Oakland, CA)
Assignee:	Cetus Corporation (Emeryville, CA)
Application Number:	06/753,717
Patent Claims:	see list of patent claims

Details for Patent 4,737,462

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bayer Healthcare Pharmaceuticals Inc.	BETASERON	interferon beta-1b	For Injection	103471	July 23, 1993	⤷ Sign Up	2005-04-12
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 4,737,462

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Country	Patent Number	Estimated Expiration
Austria	33503	⤷ Sign Up
Austria	46539	⤷ Sign Up
Austria	61407	⤷ Sign Up
Austria	73493	⤷ Sign Up
Australia	2008683	⤷ Sign Up
Australia	563962	⤷ Sign Up
Belgium	898016	⤷ Sign Up
>Country	>Patent Number	>Estimated Expiration

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