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Last Updated: December 23, 2024

TWINRIX Drug Profile


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Summary for Tradename: TWINRIX
High Confidence Patents:0
Applicants:1
BLAs:1
Recent Clinical Trials: See clinical trials for TWINRIX
Recent Clinical Trials for TWINRIX

Identify potential brand extensions & biosimilar entrants

SponsorPhase
National Institute of Allergy and Infectious Diseases (NIAID)Phase 1
Rodolphe Merieux Laboratory@@@Bamako, MaliPhase 1
National Institute of Mental Health (NIMH)Phase 2

See all TWINRIX clinical trials

Pharmacology for TWINRIX
Physiological EffectActively Acquired Immunity
Established Pharmacologic ClassInactivated Hepatitis A Virus Vaccine
Chemical StructureHepatitis A Vaccines
Vaccines, Inactivated
Note on Biologic Patents

Matching patents to biologic drugs is far more complicated than for small-molecule drugs.

DrugPatentWatch employs three methods to identify biologic patents:

  1. Brand-side disclosures in response to biosimilar applications
  2. These patents were identified from disclosures by the brand-side company, in response to a potential biosimilar seeking to launch. They have a high certainty of blocking biosimilar entry. The expiration dates listed are not estimates — they're expiration dates as indicated by the brand-side company.

  3. General brand-side disclosures
  4. These patents were identified from searching drug labels and other general disclosures from the brand-side company. This list may exclude some of the patents which block biosimilar launch, and some of these patents listed may not actually block biosimilar launch. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

  5. Patents from broad patent text search
  6. For completeness, these patents were identified by searching the patent literature for mentions of the branded or ingredient name of the drug. Some of these patents protect the original drug, whereas others may protect follow-on inventions or even inventions casually mentioning the drug. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

1) High Certainty: US Patents for TWINRIX Derived from Brand-Side Litigation

No patents found based on brand-side litigation

2) High Certainty: US Patents for TWINRIX Derived from Company Disclosures

No patents found based on company disclosures

3) Low Certainty: US Patents for TWINRIX Derived from Patent Text Search

These patents were obtained by searching patent claims

TWINRIX Market Analysis and Financial Projection Experimental

Market Dynamics and Financial Trajectory for the Biologic Drug: TWINRIX

Market Overview

TWINRIX, a combination vaccine developed to protect against both hepatitis B and hepatitis A, operates within a dynamic and growing market. Here are the key aspects of its market dynamics and financial trajectory.

Market Segmentation

The vaccine market, particularly the segment for combination vaccines like TWINRIX, is anticipated to grow significantly. This growth is driven by several factors:

Combination Vaccine Benefits

  • Combination vaccines like TWINRIX offer protection against multiple causal agents, reducing the number of injections needed and the cost associated with individual vaccines. This convenience and cost-effectiveness are major drivers for the segment's growth[4].

Geographical Expansion

  • The European Union and the UK are expected to be significant growth areas for TWINRIX and similar vaccines. Improved healthcare infrastructure, active government initiatives to track and manage hepatitis B, and well-established reimbursement systems are key factors contributing to this growth[4].

Growth Drivers

Several factors are driving the growth of the TWINRIX market:

Increasing Healthcare Expenditure

  • Rising healthcare expenditure globally is a significant driver. As more resources are allocated to healthcare, the demand for effective vaccines like TWINRIX increases[4].

Growing Geriatric Population

  • The increasing geriatric population is another critical factor. Older adults are more susceptible to hepatitis B and A, making vaccines like TWINRIX essential for this demographic[4].

Technological Advancements

  • Technological advancements in vaccine design and administration are also boosting the market. The use of AI in vaccine development and improvements in vaccine delivery systems are making vaccines more effective and accessible[4].

Government Initiatives

  • Favorable government policies and initiatives aimed at increasing vaccination rates and managing infectious diseases are further propelling the market growth[4].

Challenges

Despite the growth drivers, there are several challenges that the TWINRIX market faces:

High Cost of Vaccine Development

  • The high cost associated with developing and producing vaccines is a significant challenge. This can limit access to vaccines, especially in lower-income regions[4].

Inequitable Access to Vaccines

  • Inequitable access to vaccines remains a major issue. Disparities in healthcare access and affordability can hinder the widespread adoption of vaccines like TWINRIX[4].

Financial Trajectory

The financial performance of TWINRIX and similar combination vaccines is closely tied to the overall vaccine market trends.

Market Size and Growth

  • The global hepatitis B vaccine market, which includes combination vaccines like TWINRIX, was valued at $2.35 billion in 2022 and is expected to reach $3.04 billion by 2027, growing at a CAGR of 5.3% during this period[4].

Revenue Contribution

  • TWINRIX, being a prominent combination vaccine, contributes significantly to the revenue of its manufacturers. For instance, vaccines like TWINRIX are part of the broader vaccine portfolio of companies like GSK, which have seen strong growth in their vaccine segments. GSK's vaccine sales, including those from combination vaccines, have been a key driver of their overall revenue and profit growth[2][3].

Cost and Pricing

  • The cost-effectiveness of combination vaccines is a crucial factor. By reducing the need for multiple vaccinations, these vaccines can lower overall healthcare costs. This cost-effectiveness, combined with favorable reimbursement policies, can enhance the financial viability of TWINRIX and similar vaccines[4].

Competitive Landscape

The competitive landscape for TWINRIX involves several major players in the vaccine market:

Key Players

  • Companies like GSK, which have a strong presence in the vaccine market, are continuously investing in research and development to enhance their vaccine portfolios. GSK's acquisition of companies like Affinivax and its development of new vaccine technologies are examples of this competitive drive[2][3].

Market Share

  • The market share of TWINRIX and similar vaccines is influenced by factors such as the strength of the manufacturer's pipeline, the effectiveness of the vaccine, and the level of market penetration. Companies with strong commercial execution and competitive advantage, like GSK, tend to dominate the market[2][3].

Future Outlook

The future outlook for TWINRIX is promising, driven by several factors:

Technological Advancements

  • Ongoing technological advancements in vaccine design and administration are expected to continue driving the market. The use of AI and other innovative technologies will make vaccines more effective and accessible[4].

Expanding Indications

  • The potential expansion of indications for TWINRIX and similar vaccines to include other at-risk populations could further boost market growth. For example, vaccines like Arexvy, which initially targeted a specific age group, are now being expanded to other age groups, indicating a similar potential for TWINRIX[2].

Government Support

  • Continued government support and favorable policies aimed at increasing vaccination rates will also play a crucial role in the market's future growth[4].

Key Takeaways

  • Combination Vaccine Benefits: TWINRIX offers protection against both hepatitis B and A, reducing the need for multiple vaccinations.
  • Geographical Expansion: The European Union and the UK are key growth areas due to improved healthcare infrastructure and government initiatives.
  • Growth Drivers: Increasing healthcare expenditure, growing geriatric population, technological advancements, and government initiatives are driving the market.
  • Challenges: High cost of vaccine development and inequitable access to vaccines are significant challenges.
  • Financial Trajectory: The market is expected to grow at a CAGR of 5.3% from 2022 to 2027, with TWINRIX contributing significantly to the revenue of its manufacturers.

FAQs

What is TWINRIX?

TWINRIX is a combination vaccine that protects against both hepatitis B and hepatitis A.

What are the key growth drivers for the TWINRIX market?

Key growth drivers include increasing healthcare expenditure, a growing geriatric population, technological advancements, and favorable government initiatives.

What challenges does the TWINRIX market face?

The market faces challenges such as the high cost of vaccine development and inequitable access to vaccines.

How is the financial performance of TWINRIX expected to evolve?

The financial performance is expected to grow, driven by a CAGR of 5.3% from 2022 to 2027, with significant contributions to the revenue of its manufacturers.

What role do technological advancements play in the TWINRIX market?

Technological advancements in vaccine design and administration, including the use of AI, are making vaccines more effective and accessible, driving market growth.

Which regions are expected to see significant growth in the TWINRIX market?

The European Union and the UK are expected to be significant growth areas due to improved healthcare infrastructure and government initiatives.

Sources

  1. Data Bridge Market Research: Global Vaccine Combinations Market Size, Share, Growth, Trends, Analysis.
  2. GSK Annual Report 2023: Annual Report 2023 | GSK.
  3. GSK Annual Report 2022: Annual Report 2022 | GSK.
  4. Global Hepatitis B Virus (HBV) Vaccine Market Report 2023-2027: Global Hepatitis B Virus (HBV) Vaccine Market Report 2023-2027.

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