Effect of, OAT3, on the Renal Secretion of Cefotaxime
Completed
University of California, San Francisco
Phase 1
2004-01-01
In the proposed study, we plan to use a genotype to phenotype strategy to study the role of
the organic anion transporter, OAT3, in drug response. More specifically we will examine the
contribution of OAT3 to the renal clearance of anionic drugs such as cefotaxime by studying
individuals with a non-functional (or poorly-functional) variant of OAT3.
Randomized Trial of Continuous Versus Intermittent Cefotaxime Infusion on ICU.
Completed
University Medical Center Groningen
Phase 4
2015-11-01
This study evaluates target attainment after either intermittent intravenous bolus or
intravenous continuous infusion of cefotaxime in critically ill patients. Critically ill
patients will be randomized to intermittent infusion or continuous infusion of cefotaxime.
Disturbance of the Intestinal Microbiota by Temocillin vs Cefotaxime in Treatment of Febrile Urinary Tract Infections
Completed
Håkan Hanberger
Phase 4
2016-05-20
This study will evaluate the ecological impact on the intestinal microbiota and compare the
safety and efficacy of temocillin compared to cefotaxime, in empiric treatment of febrile
UTI. Half of participants will receive temocillin and the other half will receive cefotaxime.
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