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CLINICAL TRIALS PROFILE FOR COSELA

All Clinical Trials for COSELA

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT04799249 ↗	Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving Gemcitabine and Carboplatin for Metastatic Triple-Negative Breast Cancer (TNBC)	Recruiting	G1 Therapeutics, Inc.	Phase 3	2021-04-15	This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of trilaciclib versus placebo administered prior to gemcitabine and carboplatin in patients receiving first- or second-line treatment for locally advanced unresectable/metastatic TNBC.
NCT04863248 ↗	Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving Docetaxel for Metastatic Non-Small Cell Lung Cancer (NSCLC) (PRESERVE 4)	Recruiting	G1 Therapeutics, Inc.	Phase 2	2021-04-16	This is a randomized, double-blind, placebo-controlled, global, multicenter, Phase 2 trial evaluating the effect of trilaciclib on overall survival when administered prior to docetaxel in patients with mNSCLC treated in the 2nd or 3rd line setting.
NCT04887831 ↗	Trilaciclib, a CDK 4/6 Inhibitor, in Patients With Advanced/Metastatic Bladder Cancer Receiving Chemotherapy Then Avelumab	Recruiting	G1 Therapeutics, Inc.	Phase 2	2021-06-04	This is a Phase 2, multicenter, randomized, open-label study evaluating the safety and efficacy of trilaciclib administered with platinum-based chemotherapy followed by trilaciclib administered with avelumab maintenance therapy compared with platinum-based chemotherapy followed by avelumab maintenance therapy in patients receiving first-line treatment for advanced/metastatic bladder cancer.

Clinical Trial Conditions for COSELA

Condition Name

Condition Name for COSELA
Intervention	Trials
NSCLC	1
TNBC - Triple-Negative Breast Cancer	1
Urothelial Carcinoma	1

Condition MeSH

Condition MeSH for COSELA
Intervention	Trials
Triple Negative Breast Neoplasms	2
Breast Neoplasms	2
Carcinoma	1

Clinical Trial Locations for COSELA

Trials by Country

Trials by Country for COSELA
Location	Trials
United States	33
Ukraine	4
Poland	3
Georgia	2
Spain	2

Trials by US State

Trials by US State for COSELA
Location	Trials
Texas	3
Florida	3
California	3
Tennessee	2
Pennsylvania	2

Clinical Trial Progress for COSELA

Clinical Trial Phase

Clinical Trial Phase for COSELA
Clinical Trial Phase	Trials
Phase 3	1
Phase 2	3

Clinical Trial Status

Clinical Trial Status for COSELA
Clinical Trial Phase	Trials
Recruiting	4

Clinical Trial Sponsors for COSELA

Sponsor Name

Sponsor Name for COSELA
Sponsor	Trials
G1 Therapeutics, Inc.	4
Merck Sharp & Dohme LLC	1
Wake Forest University Health Sciences	1

Sponsor Type

Sponsor Type for COSELA
Sponsor	Trials
Industry	5
Other	1