The impact of nesiritide in CHF is unclear, but it is possible that systemic vasodilation
leads to adverse consequences even if the direct renal effects are positive. Therefore, this
study will look at the effects of direct intrarenal administration of nesiritide on GFR and
RPF.
The impact of nesiritide in CHF is unclear, but it is possible that systemic vasodilation
leads to adverse consequences even if the direct renal effects are positive. Therefore, this
study will look at the effects of direct intrarenal administration of nesiritide on GFR and
RPF.
Cardiovascular-Protective Effects of Herbal Medicine Danshen-Gegen
Completed
Chinese University of Hong Kong
Phase 2
2006-01-01
Atherosclerosis (in particular stroke and heart attack) is the most important health issue in
modernized society and high blood pressure is an important predisposing factor. Hypertensive
subjects with other chronic disease such as diabetes mellitus or impaired renal function are
particularly vulnerable to these atherosclerotic complications in spite of standard
antihypertensive therapies.
Danshen and Gegen are commonly used in Chinese materia medica as treatment for cardiac
symptoms and atherosclerosis-related disorders.
The objective of this study is to test Danshen and Gegen as an cardiovascular-protective
adjunctive regimen to prevent high-risk hypertensive cohort from primary atherosclerosis.
This was a randomized, single blind, two-period, two sequence cross-over study under fasting
condition to compare the bioavailability of two glimepiride 4 mg tablet formulations (test
and reference formulations).
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