To evaluate the effects (up to one year of age) of indomethacin on the clinical course of
patent ductus arteriosus (PDA) in premature infants (24 hours old or less) and to assess the
relative merits of indomethacin and surgery in infants with persistent respiratory distress
who were not treated early with indomethacin. Two concurrent trials were performed.
Indomethacin Plus Biological Therapy in Treating Patients With Advanced Melanoma
Completed
St. Luke's Medical Center
Phase 2
1993-07-01
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop
tumor cells from growing. Combining biological therapies with indomethacin and
cyclophosphamide may kill more tumor cells.
PURPOSE: Phase II trial to compare the effectiveness of indomethacin and biological therapy
with or without cyclophosphamide in treating patients who have advanced melanoma that has not
responded to previous therapy.
Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer
Terminated
National Cancer Institute (NCI)
Phase 1/Phase 2
1997-05-01
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop
growing or die. Interferon-gamma may interfere with the growth of tumor cells and slow the
growth of the tumor. Combining more than one drug with interferon-gamma may kill more tumor
cells. This phase I/II trial is studying the side effects and best dose of giving
fluorouracil together with phenylbutyrate, indomethacin, and interferon-gamma and to see how
well it works in treating patients with stage IV colorectal cancer
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