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Last Updated: November 22, 2024

CLINICAL TRIALS PROFILE FOR LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE


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All Clinical Trials for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00001724 ↗ Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction Completed National Institute of Dental and Craniofacial Research (NIDCR) Phase 2 1997-11-01 This study will evaluate the effectiveness of the non-steroidal anti-inflammatory drug flurbiprofen (Ansaid® (Registered Trademark)) in relieving pain following oral surgery. Flurbiprofen is approved by the Food and Drug Administration for treatment of arthritis pain. Patients 16 years of age and older requiring third molar (wisdom tooth) extraction may be eligible for this study. Patients will undergo oral surgery to remove two lower third molar teeth. Before surgery, they will be given a local anesthetic (lidocaine with epinephrine) injected in the mouth and a sedative (Versed) infused through a catheter (thin plastic tube) placed in an arm vein. At the time of surgery, patients will also be given flurbiprofen or a placebo formulation (look-alike substance with no active ingredient) directly into the extraction site and a capsule that also may contain flurbiprofen or placebo. One in seven patients will receive only placebo. All patients will fill out pain questionnaires and stay in the clinic for up to 6 hours for observation of bleeding and medication side effects. Patients who do not have satisfactory pain relief from the test medicine after surgery may request a standard pain reliever. A small blood sample will be collected during surgery and at 15 minutes, one-half hour and 1, 2, 3, 4, 5, 6, 24 and 48 hours after surgery to measure flurbiprofen blood levels. A total of 33 ml (about 2 tablespoons) of blood will be drawn for these tests. Samples collected on the day of surgery will be drawn from the catheter used to administer the sedative; the 24- and 48-hour samples will be taken by needle from an arm or hand vein. Urine samples will also be collected between 4 and 6 hours after surgery and again at 24 and 48 hours after surgery.
NCT00107822 ↗ Safety Study of S-Caine Peel (Skin Numbing Cream) Before a Painful Dermatologic Procedure in Children Completed ZARS Pharma Inc. Phase 3 2005-04-01 The purpose of this study is to evaluate the safety of one treatment of S-Caine™ Peel (skin numbing cream) applied on healthy skin before a painful dermatologic procedure in children. This study will also evaluate how well the S-Caine™ Peel eases the pain of the procedure.
NCT00107835 ↗ Safety Study of S-Caine Peel (Skin Numbing Cream) Before a Painful Dermatologic Procedure in Adults Completed ZARS Pharma Inc. Phase 3 2005-05-01 The purpose of this study is to evaluate the safety of one treatment of S-Caine™ Peel (skin numbing cream) applied on healthy skin before a painful dermatologic procedure in adults. This study will also evaluate how well the S-Caine™ Peel eases the pain of the procedure.
NCT00154167 ↗ Safety and Efficacy Study of NV-101 in Dental Patients Completed Novalar Pharmaceuticals, Inc. Phase 2 2003-02-01 The purpose of this study was: - to determine if NV-101 accelerates recovery from numbness compared to placebo - to evaluate safety of NV-101
NCT00194610 ↗ Botox as a Treatment for Interstitial Cystitis in Women Completed Paul G. Allen Family Foundation Phase 4 2004-05-01 Patients with interstitial cystitis have been well documented to have pelvic floor muscle tenderness as well as pain on bladder distension. Some investigators have even suggested that pelvic floor muscle pain is primarily the cause of bladder problems. Botulinum toxin A causes muscle relaxation by inhibiting the acetylcholine release at the neuromuscular junction. It has been shown that this mechanism relieves pain in a number of muscle spasm-related syndromes. Because, at present, there is little effective therapy available for patients with interstitial cystitis, the researchers want to determine if botulinum toxin A will relieve bladder and pelvic pain in these patients.
NCT00194610 ↗ Botox as a Treatment for Interstitial Cystitis in Women Completed University of Washington Phase 4 2004-05-01 Patients with interstitial cystitis have been well documented to have pelvic floor muscle tenderness as well as pain on bladder distension. Some investigators have even suggested that pelvic floor muscle pain is primarily the cause of bladder problems. Botulinum toxin A causes muscle relaxation by inhibiting the acetylcholine release at the neuromuscular junction. It has been shown that this mechanism relieves pain in a number of muscle spasm-related syndromes. Because, at present, there is little effective therapy available for patients with interstitial cystitis, the researchers want to determine if botulinum toxin A will relieve bladder and pelvic pain in these patients.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE

Condition Name

Condition Name for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE
Intervention Trials
Pain 25
Anesthesia, Local 11
Pain, Postoperative 10
Anesthesia 9
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Condition MeSH

Condition MeSH for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE
Intervention Trials
Pain, Postoperative 27
Pulpitis 26
Acute Pain 10
Lacerations 8
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Clinical Trial Locations for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE

Trials by Country

Trials by Country for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE
Location Trials
United States 117
Canada 16
Egypt 9
Saudi Arabia 7
Germany 6
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Trials by US State

Trials by US State for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE
Location Trials
California 23
New York 10
Pennsylvania 9
North Carolina 7
Maryland 7
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Clinical Trial Progress for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE

Clinical Trial Phase

Clinical Trial Phase for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE
Clinical Trial Phase Trials
Phase 4 85
Phase 3 22
Phase 2/Phase 3 9
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Clinical Trial Status

Clinical Trial Status for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE
Clinical Trial Phase Trials
Completed 129
Not yet recruiting 27
Recruiting 26
[disabled in preview] 32
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Clinical Trial Sponsors for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE

Sponsor Name

Sponsor Name for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE
Sponsor Trials
University of California, San Diego 6
University of North Carolina, Chapel Hill 5
University of Pennsylvania 4
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Sponsor Type

Sponsor Type for LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE
Sponsor Trials
Other 263
Industry 28
U.S. Fed 8
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