Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria
Completed
Colgate Palmolive
Phase 4
2014-01-01
The primary objective was to evaluate the antibacterial effects of two toothpastes containing
0.3% triclosan, 2% copolymer and 0.234% sodium fluoride in a silica base as compared to a
control regular fluoride toothpaste on anaerobic and malodor bacteria 12 hours after 13 days
of product use. A secondary objective was to demonstrate that a toothpaste containing 0.3%
triclosan, 2% copolymer, 0.234% sodium fluoride and a flavor with odor-masking ingredients in
silica base (Colgate Total Toothpaste-Flavor Option 1) provides a level of antibacterial
efficacy that is "equivalent" to a toothpaste containing 0.3% triclosan, 2% copolymer, 0.234%
sodium fluoride and a regular flavor in silica base (Colgate Total Toothpaste-Flavor Option
2) after 13 days of product use.
Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)
Completed
Colgate Palmolive
Phase 4
2014-06-01
The objective of this clinical research study is to assess the efficacy of a commercially
available triclosan/copolymer toothpaste compared to a commercially available oral hygiene
multi-component regimen encompassing the use of a manual toothbrush, a toothpaste containing
stannous fluoride / sodium hexametaphosphate and a mouthwash containing cetylpyridinium
chloride relative to a negative control regimen in reducing established dental plaque and
gingivitis over three and six months of assigned product use.
Triclosan Toothpaste in the Maintenance Phase of Peri-implantitis Treatment.
Completed
Universidade Estadual de Maringá
Phase 3
2010-06-01
The aim of this study was to evaluate the effects of a dentifrice containing 0.3% triclosan
on periodontal and peri-implant parameters in patients, with or without periodontitis,
treated for peri-implantitis and that were enrolled in a maintenance phase for two years.
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