A Comparison of Telmisartan + Hydrochlorothiazide With Amlodipine + Hydrochlorothiazide in the Control of Blood Pressure in Older Patients With Predominantly Systolic Hypertension (ATHOS Study)
Completed
Boehringer Ingelheim
Phase 4
2002-12-01
The primary objective of this study was test non-inferiority of telmisartan 80 mg +
hydrochlorothiazide (HCTZ) 12.5 mg in comparison to amlodipine 10 mg + HCTZ 12.5 mg in
reducing ambulatory systolic blood pressure (SBP) in the last 6 hours of the 24-hour dosing
interval (determined by ambulatory blood pressure monitoring: ABPM) in elderly patients with
predominantly systolic hypertension.
Phase IV, 9 Weeks Comparison Between MICARDIS 80 mg and Amlodipine 10 mg on Biological PPAR Gamma Activities
Completed
Boehringer Ingelheim
Phase 4
2005-10-01
The objective of the study is to compare PPAR activities (increase of adiponectin level)
between MICARDIS and amlodipine after 6 weeks of treatment in hypertensive patients with
metabolic syndrome. Moreover, this study will compare serum level of inflammatory markers of
the metabolic syndrome after 6 weeks of treatment.
An ancillary study performed in one center will assess adipocyte differentiation (PPAR gamma
stimulation) in 30 subjects (15 per arm).
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