Comparison of Foscarnet Versus Vidarabine in the Treatment of Herpes Infection in Patients With AIDS Who Have Not Had Success With Acyclovir
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
Phase 3
1969-12-31
To compare the safety and effectiveness of foscarnet and vidarabine treatments for AIDS
patients who have herpes simplex virus infections that are resistant to standard treatment
with acyclovir.
Foscarnet is a drug that inhibits viruses and has been shown to be effective against
infection with Cytomegalovirus and also against infection with the Herpes simplex virus in
several patients with AIDS. Vidarabine has been shown to have activity against the Herpes
simplex virus in patients who do not have AIDS, but it has not been studied in patients who
do have AIDS. This study compares foscarnet and vidarabine treatments for AIDS patients who
have herpes simplex infection that has not responded to therapy with acyclovir in the hope
that one of these two drugs will help to stop further progression of the herpes simplex
infection and may have fewer side effects.
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