The CATIE Schizophrenia Trial is part of the Clinical Antipsychotic Trials of Intervention
Effectiveness (CATIE) Project. The schizophrenia trial is being conducted to determine the
long-term effects and usefulness of antipsychotic medications in persons with schizophrenia.
It is designed for people with schizophrenia who may benefit from a medication change. The
study involves the newer atypical antipsychotics (olanzapine, quetiapine, risperidone,
clozapine, and ziprasidone)and the typical antipsychotics (perphenazine and fluphenazine
decanoate). All participants will receive an initial comprehensive medical and psychiatric
evaluation and will be closely followed throughout the study. For most participants the study
will last up to 18 months. Everyone in the study will be offered an educational program about
schizophrenia and family members will be encouraged to participate.
This study will evaluate the effectiveness of switching medications in decreasing
schizophrenia symptoms in individuals who are currently taking an antipsychotic medication
for the treatment of schizophrenia.
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