Methadone Effects on Zidovudine (ZDV, AZT) Disposition
Completed
Glaxo Wellcome
Phase 1
1969-12-31
To determine whether methadone maintenance alters the pharmacokinetics of zidovudine (AZT).
To determine whether any such effect of methadone on disposition of AZT is time dependent and
whether a metabolic interaction between AZT and methadone exists.
Injection drug users represent an increasing proportion of HIV-infected persons. Since daily
methadone maintenance is the major chemical treatment for injection drug abuse, it is
important to determine the impact of methadone on AZT absorption, distribution, and
elimination.
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