Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction
Completed
Novartis Pharmaceuticals
Phase 3
2014-07-18
The purpose of this study was to evaluate the effect of LCZ696 compared to valsartan in the
reduction of cardiovascular death and heart failure(HF) hospitalizations in patients with HF
with preserved ejection fraction.
Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.
Completed
Novartis Pharmaceuticals
Phase 4
2016-04-29
The purpose of this study was to assess the effect of in-hospital initiation of
sacubitril/valsartan (LCZ696) vs. enalapril on time averaged proportional change in NT-proBNP
in patients who have been stabilized following hospitalization for acute decompensated heart
failure (ADHF) and reduced ejection fraction (left ventricular ejection fraction (LVEF) ≤
40%).
Use of Entresto Sacubitril/Valsartan for the Treatment of Peripheral Arterial Disease
Terminated
American Heart Association
Phase 2
2017-12-31
This study proposes the use of Entresto (sacubitril/valsartan) to test the effects on pain
free walking duration on patients with peripheral arterial disease, a condition caused by
decreased blood flow to the muscles in the legs.
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