Pharmacodynamic Study of AZD1722 in End-stage Renal Disease Patients on Hemodialysis
Completed
AstraZeneca
Phase 2
2013-01-01
The purpose of this study is to determine if the study drug is safe, tolerable and active in
reducing fluid overload/weight gain between dialysis sessions for patients with End Stage
Renal Disease on Hemodialysis.
Pharmacodynamic Study of AZD1722 in End-stage Renal Disease Patients on Hemodialysis
Completed
Ardelyx
Phase 2
2013-01-01
The purpose of this study is to determine if the study drug is safe, tolerable and active in
reducing fluid overload/weight gain between dialysis sessions for patients with End Stage
Renal Disease on Hemodialysis.
Safety, Tolerability, Pharmacokinetics and Pharmacodynamic of AZD1722 in Healthy Male and Female Japanese Subjects
Completed
AstraZeneca
Phase 1
2013-07-01
The study is designed to evaluate the safety, tolerability, pharmacodynamics and
pharmacokinetics of AZD1722 in healthy Japanese subjects at increasing doses given for 7 days
in order to allow for including Japanese subjects in future global studies. A cohort of
Caucasian subjects will be included in the study to evaluate cardiac effects, assessed by
digital ECGs (dECG) recordings, also in Caucasian subjects.
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