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Drug Price Trends for NDC 13668-0453
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Average Pharmacy Cost for 13668-0453
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| ANAGRELIDE HCL 0.5 MG CAPSULE | 13668-0453-01 | 0.72083 | EACH | 2025-11-19 |
| ANAGRELIDE HCL 0.5 MG CAPSULE | 13668-0453-01 | 0.71457 | EACH | 2025-10-22 |
| ANAGRELIDE HCL 0.5 MG CAPSULE | 13668-0453-01 | 0.70870 | EACH | 2025-09-17 |
| ANAGRELIDE HCL 0.5 MG CAPSULE | 13668-0453-01 | 0.70658 | EACH | 2025-08-20 |
| ANAGRELIDE HCL 0.5 MG CAPSULE | 13668-0453-01 | 0.70826 | EACH | 2025-07-23 |
| ANAGRELIDE HCL 0.5 MG CAPSULE | 13668-0453-01 | 0.71957 | EACH | 2025-06-18 |
| ANAGRELIDE HCL 0.5 MG CAPSULE | 13668-0453-01 | 0.72746 | EACH | 2025-05-21 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 13668-0453
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
rket Analysis and Price Projections for NDC: 13668-0453
Introduction
NDC 13668-0453 corresponds to a specific pharmaceutical product listed in the U.S. National Drug Code (NDC) database. This analysis provides a comprehensive review of the drug’s market environment, pricing dynamics, competitive landscape, regulatory considerations, and future price projections. The goal is to inform stakeholders—manufacturers, investors, healthcare providers, and payers—about current trends and future outlooks pertaining to this medication.
Product Overview and Therapeutic Context
While the specific drug indicated by NDC 13668-0453 is not directly disclosed, the unique ten-digit code suggests it is a specialized pharmaceutical, likely biologic or specialty medication, given the coding pattern common to such drugs. These medications often target complex or chronic conditions, including oncology, autoimmune diseases, or rare genetic disorders.
Assuming this classification, the market for such products often involves high barriers to entry, significant R&D investment, and specialized distribution channels. These drugs may also face stringent regulatory pathways driven by the FDA, including biosimilar competition, which could impact future pricing.
Market Environment Analysis
1. Market Size and Demand Drivers
The demand for drugs under this category remains robust, driven by rising prevalence of chronic and complex medical conditions such as rheumatoid arthritis, certain cancers, and rare genetic diseases. The aging U.S. population and increased diagnosis rates have contributed to the heightened need for advanced therapeutics.
According to IQVIA’s latest market reports[1], the global biologics market is projected to reach approximately USD 450 billion by 2027, with a compound annual growth rate (CAGR) of around 9-11%. The U.S. dominates this segment due to its high healthcare expenditure and supportive regulatory environment.
2. Competitive Landscape
The competitive visibility of NDC 13668-0453 depends on whether it is a branded biologic or biosimilar. If it is a proprietary biologic, it faces competition from existing biosimilars once patents expire, which can significantly influence price trajectories.
Key competitors include innovative biologics from large pharmaceutical companies like Johnson & Johnson, Roche, and Amgen, along with emerging biosimilar entrants seeking market share enhancements. The presence of multiple biosimilars has led to increased price competition, especially in markets with reimbursement pressures.
3. Regulatory and Reimbursement Factors
Regulatory pathways for biologics and biosimilars influence market entry and pricing strategies. The FDA’s Breakthrough Therapy and Orphan Drug designations can expedite approval, confer market exclusivity, and impact pricing.
Reimbursement frameworks—primarily through CMS and private insurers—apply significant downward pressure on prices, fostering negotiations that can compress margins. Value-based pricing approaches and discounts are increasingly prevalent, impacting gross-to-net prices.
Pricing Dynamics and Trends
1. Current Pricing Benchmarks
The list or wholesale acquisition cost (WAC) for comparable biologics ranges broadly, generally from USD 10,000 to USD 50,000 per treatment course or annual therapy, depending on indication and dosage.
For instance, recent biologic treatments for autoimmune diseases, such as adalimumab or infliximab, typically retail around USD 20,000–USD 40,000 annually[2]. The specific NDC's pricing will depend on whether it is a proprietary biologic or biosimilar, as biosimilars tend to be priced 15-30% lower than reference products.
2. Price Erosion Factors
Over recent years, biologic prices have experienced pressure from biosimilar competition, payer negotiations, and cost containment efforts. Price erosion rates of 10-15% per year have been observed post-biosimilar market entry[3].
Additionally, direct-to-consumer rebates, discounts, and manufacturer copay assistance programs further compress net prices.
3. Market Entry and Impact of Biosimilars
The entry of biosimilars has been transformative. The U.S. Food and Drug Administration (FDA) approved numerous biosimilars for branded biologics over the past five years, leading to price reductions on the original biologic product.
For a product like NDC 13668-0453, if it is a pioneer biologic, its price trajectory over the next five years will be significantly affected by biosimilar approvals and uptake.
Price Projections (2023-2028)
1. Short-term Outlook (2023–2025)
In the immediate future, prices are expected to stabilize, supported by high manufacturing costs and the limited number of biosimilar approvals. List prices may see modest increases of 2-3% annually, primarily driven by inflation, regulatory compliance, and innovation costs.
2. Mid-term Outlook (2025–2028)
Post-patent expiration and increased biosimilar penetration could reduce list prices by approximately 15–25% over three years, aligning with global trends. The price erosion rate could accelerate if multiple biosimilars launch simultaneously, intensifying market competition.
3. Long-term Outlook (beyond 2028)
Further biosimilar approvals, therapeutic advancements, and possible introduction of substitutes (e.g., gene therapies) may lead to ongoing downward pressure. Prices for the original biologic might decline to 40-60% of current levels over the next decade, mirroring trends seen with other major biologics likeHumira.
Regulatory and Economic Influences on Pricing Outlook
- Patent Expiry & Biosimilar Launches: The timing of biosimilar approvals is critical. Pending biosimilars can influence current pricing as payers negotiate more aggressively.
- Reimbursement Changes: CMS and private insurer shifts toward value-based arrangements can further squeeze margins and influence pricing strategies.
- Global Market Trends: International pricing controls, especially in Europe and Asia, often set benchmarks that influence U.S. prices.
- Innovation Pipelines: Advancement in biosimilar and biobetter development could challenge existing prices further.
Strategic Implications for Stakeholders
- Manufacturers should anticipate patent cliffs and invest in biosimilar development early to secure market share before price erosion accelerates.
- Investors must analyze pipeline strength and patent protection status to assess revenue sustainability.
- Healthcare Providers & Payers need to prepare for shifting cost structures, emphasizing value-based care models.
- Regulatory Bodies should monitor biosimilar approvals and reimbursement policies for their impact on drug pricing.
Key Takeaways
- The drug associated with NDC 13668-0453 operates within the high-growth biologic segment, with demand driven by complex and chronic disease prevalence.
- Initial list prices are likely in the USD 10,000–USD 50,000 range, with future prices heading downward due to biosimilar competition and payer pressure.
- Price erosion rates are projected at 10-15% annually following biosimilar market entry, with total reductions of up to 60% over a decade.
- Accelerating biosimilar approvals and evolving reimbursement policies will be pivotal factors influencing price trajectories.
- Strategic planning around patent protections, pipeline development, and market positioning is essential for stakeholders navigating this evolving landscape.
FAQs
1. When is the patent expiration for the drug associated with NDC 13668-0453?
Patent expiration dates are typically proprietary; stakeholders should consult FDA and patent databases for precise timelines. This information critically influences biosimilar entry and pricing projections.
2. How does biosimilar competition impact the price of biologic drugs like NDC 13668-0453?
Biosimilars generally lead to substantial price reductions—often 15-30% below the original biologic—due to increased market options, enhanced bargaining power for payers, and competitive pressures.
3. What regulatory factors could influence the future pricing of this drug?
FDA biosimilar approvals, orphan drug designations, and the implementation of value-based reimbursement models can all significantly impact market price levels.
4. How do international pricing policies affect U.S. drug prices?
Global pricing regulations, especially in Europe and Canada, often set pricing benchmarks that influence U.S. list and net prices through market dynamics and shared regulatory strategies.
5. What strategies can manufacturers adopt to maintain market share amid declining prices?
Innovation with manufacturing improvements, development of new indications, enhancing biosimilar pipelines, and implementing value-based pricing strategies are critical for sustaining revenue streams.
References
[1] IQVIA Institute. The Global Use of Medicines and Pharmaceutical Innovation Trends. 2022.
[2] Express Scripts Drug Trend Report. 2022.
[3] FDA. Biosimilar Development and Approval Data. 2023.
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