Claims for Patent: 10,016,429

Summary for Patent: 10,016,429

Title:	Salts of the janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile
Abstract:	The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile that are useful in the modulation of Janus kinase activity and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
Inventor(s):	Rodgers; James D. (Bethany Beach, DE), Li; Hui-Yin (Hockessin, DE)
Assignee:	INCYTE CORPORATION (Wilmington, DE) INCYTE HOLDINGS CORPORATION (Wilmington, DE)
Application Number:	15/164,518
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 10,016,429
Patent Claims:	1. A method of treating a disease selected from allograft rejection and graft versus host disease in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of a compound that is (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile phosphoric acid salt. 2. The method of claim 1, wherein the disease is allograft rejection. 3. The method of claim 1, wherein the disease is graft versus host disease. 4. The method of claim 1, wherein (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile phosphoric acid salt is a crystalline salt. 5. The method of claim 4, wherein said crystalline salt is a 1:1 (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile:phosphoric acid salt. 6. A method of treating a disease selected from allograft rejection and graft versus host disease in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of a pharmaceutical composition comprising (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile phosphoric acid salt and a pharmaceutically acceptable carrier. 7. The method of claim 6, wherein the disease is allograft rejection. 8. The method of claim 6, wherein the disease is graft versus host disease. 9. The method of claim 6, wherein the pharmaceutical composition is suitable for oral administration. 10. The method of claim 6, wherein the pharmaceutical composition is in tablet form. 11. The method of claim 6, wherein (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile phosphoric acid salt is a crystalline salt. 12. The method of claim 11, wherein said crystalline salt is a 1:1 (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile:phosphoric acid salt.