Claims for Patent: 10,722,522

Summary for Patent: 10,722,522

Title:	Dosing regimen for sedation with CNS 7056 (remimazolam)
Abstract:	The invention relates to a dosing regimen for sedation with the fast-acting benzodiazepine CNS 7056 in combination with an opioid, in particular fentanyl, whereas CNS 7056 is given in a dose of 2 to 20 mg, preferably between 4 and 9 mg and most preferably between 5 and 8 mg.
Inventor(s):	Wilhelm-Ogunbiyi; Karin (Simmermath, DE), Borkett; Keith (Houghton Camps, GB), Tilbrook; Gary Stuart (Huntingdon, GB), Wiltshire; Hugh (Digswell, GB)
Assignee:	PAION UK LTD. (Histon Cambridge, GB)
Application Number:	16/457,387
Patent Claims:	1. A method of sedating an adult subject comprising: administering intravenously to the subject a 5 mg initial dose over a period of 1 minute of 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazol[1,2-a][1,4- ]benzodiazepine-4-yl]-propionic methyl ester of formula (I) ##STR00003## or a pharmaceutically acceptable salt thereof. 2. The method of claim 1, further comprising administering to the subject at least one supplemental dose given after the initial dose or a previous top-up dose the compound of formula (I), or a pharmaceutically acceptable salt thereof. 3. The method of claim 2, wherein the at least one supplemental dose is administered not less than 2 minutes after the initial dose or a previous top-up dose. 4. The method of claim 2, wherein the at least one supplemental dose given after the initial dose or a previous top-up dose is in an amount of between about 2 mg and 3 mg. 5. The method of claim 4, wherein the at least one supplemental dose is administered not less than 2 minutes after the initial dose. 6. The method of claim 1, wherein the pharmaceutically acceptable salt is a besylate salt. 7. The method of claim 1, wherein the adult subject is sedated for less than 30 minutes. 8. The method of claim 1, further comprising maintaining a patient airway or positive pressure ventilation in the subject.