Claims for Patent: 11,083,730

Summary for Patent: 11,083,730

Title:	Long-acting polymeric delivery systems
Abstract:	Compositions comprised of a delivery vehicle or delivery system and an active agent dispersed within the delivery vehicle or system, wherein the delivery vehicle or system contains a polyorthoester polymer and a polar aprotic solvent. Also disclosed are low viscosity delivery systems for administration of active agents. The low viscosity delivery systems have a polyorthoester polymer, a polar aprotic solvent and a solvent containing a triglyceride viscosity reducing agent. Compositions described include an amide- or anilide-type local anesthetic of the "caine" classification, and a non-steroidal anti-inflammatory drug (NSAID), along with related methods, e.g., for treatment of post-operative pain or for prophylactic treatment of pain. The compositions are suitable for delivery via, e.g., direct application and instillation, intradermal injection, subcutaneous injection, and nerve block (perineural).
Inventor(s):	Ottoboni; Thomas B. (Belmont, CA), Girotti; Lee Ann Lynn (San Bruno, CA)
Assignee:	Heron Therapeutics, Inc. (San Diego, CA)
Application Number:	15/331,759
Patent Claims:	1. A pharmaceutical composition, which comprises a delivery system, an amide local anesthetic, and meloxicam, wherein the amide local anesthetic and meloxicam are present in the composition at a ratio ranging from about 10:1 to 50:1, and wherein the composition contains no additional active agents. 2. The composition of claim 1, wherein the amide local anesthetic is bupivacaine. 3. The composition of claim 1, wherein the amide local anesthetic is ropivacaine. 4. The composition of claim 1, wherein the amide local anesthetic is present in the composition in an amount ranging from about 0.1 to 8.0 wt % and the meloxicam in present in the composition in an amount ranging from about 0.005% to 1%. 5. The composition of claim 1, wherein the delivery system is a sustained-release delivery system. 6. The composition of claim 1, wherein the delivery system is aqueous based. 7. The composition of claim 5, wherein the sustained-release delivery system is a polymeric formulation, a liposome, a microsphere, an implantable device or a non-polymeric formulation. 8. The composition of claim 5, wherein the sustained-release delivery system is a liposome selected from the group consisting of small unilamellar vesicles (SUV), large unilamellar vesicles (LUV), multi-lamellar vesicles (MLV) and multivesicular liposomes (MVL). 9. The composition of claim 8, wherein the amide local anesthetic and the meloxicam are entrapped in an aqueous space of the liposome or in a lipid layer of the liposome. 10. The composition of claim 5, wherein the sustained-release delivery system is a microsphere comprised of a bioerodible or biodegradable polymer. 11. The composition of claim 10, wherein the amide local anesthetic and the meloxicam are entrapped in the microsphere. 12. The composition of claim 7, wherein the implantable device is an osmotic pump with a reservoir comprising the amide local anesthetic and the meloxicam. 13. The composition of claim 5, wherein the sustained-release delivery system is a non-polymeric formulation comprising sucrose acetate isobutyrate. 14. The composition of claim 5, wherein the sustained-release delivery system is a polymeric formulation in the form of a semi-solid polymer formulation comprising a polymer, the amide local anesthetic and the meloxicam. 15. The composition of claim 14, wherein the polymer is a bioerodible or biodegradable polymer. 16. The composition of claim 14, wherein the polymer formulation forms an implant or depot in situ. 17. The composition of claim 14 wherein the polymer is selected from the group consisting of polylactides, polyglycolides, poly(lactic-co-glycolic acid) copolymers, polycaprolactones, poly-3-hydroxybutyrates, and polyorthoesters. 18. The composition of claim 14, wherein the polymer is a polyorthoester. 19. The composition of claim 17, wherein the polyorthoester in the composition is selected from the polyorthoesters represented by Formulas I, II, III and IV: ##STR00033## wherein R is a bond, --(CH.sub.2).sub.a--, or --(CH.sub.2).sub.b--O--(CH.sub.2).sub.c--; where a is an integer from 1 to 12, and b and c are independently integers from 1 to 5; R* is a C.sub.1-4 alkyl; R.sup.o, R'' and R''' are each independently H or C.sub.1-4 alkyl; n is an integer of at least 5; and A is a diol that is R.sup.1, R.sup.2, R.sup.3, or R.sup.4, where R.sup.1 is ##STR00034## R.sup.5 is hydrogen or C.sub.1-4 alkyl; and R.sup.6 is selected from the group consisting of: ##STR00035## where: s is an integer ranging from 0 to 10; t is an integer ranging from 2 to 30; and R.sup.7 is hydrogen or C.sub.1-4 alkyl; R.sup.2 is: ##STR00036## R.sup.3 is: ##STR00037## where: x is an integer ranging from 0 to 200; y is an integer ranging from 2 to 30; R.sup.8 is hydrogen or C.sub.1-4 alkyl; R.sup.9 and R.sup.10 are independently C.sub.1-12 alkylene; R.sup.11 is hydrogen or C.sub.1-6 alkyl and R.sup.12 is C.sub.1-6 alkyl; or R.sup.11 and R.sup.12 together are C.sub.3-10 alkylene; and R.sup.4 is the residue of a diol containing at least one functional group independently selected from an amide, an imide, a urea, and a carbmate group. 20. The composition of claim 17, wherein the polyorthoester is represented by Formula I: ##STR00038## where: R* is a C.sub.1-4 alkyl, n is an integer ranging from 5 to 400, and A is a diol, where A is R.sup.1 and/or R.sup.3, where the fraction of A units that are of formula R.sup.1 is between 0 and 25 mole percent, where when A is R.sup.3, R.sup.3 is ##STR00039## where x is 2; and when A is R.sup.1, R.sup.1 is ##STR00040## R.sup.5 is H, and R.sup.6 is ##STR00041## the sum of p and q is, on average, 2 and s is 2, where the resulting component of the polyorthoester comprises the subunit ##STR00042## 21. The composition of claim 1, wherein the delivery system comprises a polyorthoester, a polar aprotic solvent and a triglyceride viscosity reducing agent, wherein the triglyceride viscosity reducing agent comprises three fatty acid groups each independently comprising between 1-7 carbon atoms, and wherein the amide local anesthetic and meloxicam are present in the delivery system at a ratio ranging from about 10:1 to 50:1. 22. The composition of claim 21, wherein the triglyceride viscosity reducing agent is selected from the group consisting of triacetin and tributyrin. 23. The composition of claim 21, wherein the polar aprotic solvent is selected from dimethylsulfoxide, N-methyl pyrrolidone and dimethyl acetamide. 24. The composition of claim 21, wherein the amide local anesthetic and meloxicam are soluble in the triglyceride viscosity reducing agent, the polar aprotic solvent, or a mixture thereof. 25. The composition of claim 21, wherein the amide local anesthetic is present in the delivery system at between about 0.01 wt % and about 7.5 wt % of the delivery system. 26. The composition of claim 25, wherein the meloxicam is present in the delivery system at between about 0.005 wt % to 0.25 wt % of the delivery system. 27. The composition of claim 1, wherein the delivery system comprises: 40 wt % to 75 wt % of a polyorthoester; 5 wt % to 12 wt % dimethyl sulfoxide; 20 wt % to 40 wt % triacetin; 1 wt % to 5 wt % bupivacaine or ropivacaine; and 0.005 wt % to 1 wt % meloxicam. 28. The composition of claim 27, wherein the delivery system further comprises 0.01 wt % to 0.30 wt % maleic acid. 29. The composition of claim 27, wherein the polyorthoester is represented by the structure shown as Formula I: ##STR00043## where R* is C.sub.1-4 alkyl, n ranges from 5 to 400, and A is a diol. 30. The composition of claim 29, where A is R.sup.1 and/or R.sup.3, where fraction of A units that are of formula R.sup.1 is between 0 and 25 mole percent, R.sup.1 is ##STR00044## p and q are each independently integers ranging from between about 1 and 20 and the average number of p or the average sum of p and q is between about 1 and 7, and R.sup.5 is H or methyl, R.sup.6 is ##STR00045## where s is an integer ranging from 0 to 10, and R.sup.3 is ##STR00046## where x is an integer ranging from 1 to 10. 31. The composition of claim 30, wherein s is 2 and x is 2. 32. The composition of claim 30, wherein R.sup.3 and R.sup.6 are both --(CH.sub.2--CH.sub.2--O).sub.2--(CH.sub.2--CH.sub.2)--; R.sup.5 is H; and p is 1 or 2. 33. The composition of claim 30, wherein R.sup.5 is hydrogen. 34. The composition of claim 30, wherein when A is R.sup.1, R.sup.1 is ##STR00047## R.sup.5 is H, and R.sup.6 is ##STR00048## where the resulting polyorthoester comprises the subunit ##STR00049## where the sum of p and q is, on average, 2 and s is 2, and when A is R.sup.3, x is 2. 35. The composition of claim 30, wherein the fraction of A units that are of formula R.sup.1 is about 20 mole percent. 36. The composition of claim 27, wherein the polyorthoester has a weight average molecular weight between 2,500 daltons and 10,000 daltons. 37. The composition of claim 27, wherein the delivery system has a viscosity less than 10000 mPa-s when measured at 37.degree. C. using a viscometer. 38. The composition of claim 27, wherein the bupivacaine or ropivacaine and the meloxicam are solubilized in a single phase. 39. The composition of claim 27, wherein the composition is an extended-release composition. 40. The composition of claim 5, wherein the amide local anesthetic is released from the composition over a time period of about 1 day to about 5 days. 41. A method for producing analgesia or pain relief in a subject in need thereof, comprising: administering to the subject the composition according to claim 1. 42. A method for managing pain in a subject in need thereof, comprising administering to the subject the composition according to claim 1. 43. A method for prophylactic treatment of pain in a subject, comprising administering to the subject the composition according to claim 1. 44. The method of claim 41, wherein the administering is intramuscular, subcutaneous, perineural or to a wound. 45. The method of claim 41, wherein the pain is acute pain or chronic pain. 46. The method of claim 41, wherein the composition or delivery system is administered to a surgical wound. 47. The method according to claim 46, wherein the pain is postsurgical pain. 48. The method of claim 41, wherein the composition produces pain relief for a time period of about 3 days to about 5 days following administration. 49. The method of claim 41, wherein the composition or delivery system is administered as a nerve block. 50. The method of claim 41, wherein the composition or delivery system is administered as a peripheral nerve block. 51. The method of claim 41, further comprising administering the composition to a person in need thereof, whereby said administering provides, as measured in an in vivo model for postsurgical pain, an initial decrease in pain relief between about 1 hour and 24 hours after administering and a period of increased pain relief between about 1-3 days after administering, wherein the initial decrease in pain relief is with respect to pain relief provided immediately after administering. 52. The method of claim 51, wherein the composition provides pain relief over days 2 to 5 following administration that is at least, on average, about 50% of the average pain relief provided by the composition 1-5 hours post-administration. 53. The method of claim 51, whereby the administering is effective to provide a measurable plasma concentration of the amide local anesthetic and of the meloxicam for a period up to 5 days following administration. 54. The method of claim 51, wherein about 80% by weight or more of both the amide local anesthetic and the meloxicam are released from the composition over a period of up to about 3 days when measured in an in vitro test at 37.degree. C.