Claims for Patent: 11,123,305

Summary for Patent: 11,123,305

Title:	Patch
Abstract:	In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.
Inventor(s):	Sonobe; Atsushi (Tsukuba, JP), Yasukochi; Takashi (Tsukuba, JP), Takada; Yasunori (Tsukuba, JP)
Assignee:	HISAMITSU PHARMACEUTICAL CO., INC. (Tosu, JP)
Application Number:	16/008,704
Patent Claims:	1. A patch, comprising: a support layer; and an adhesive agent layer formed on the support layer and comprising asenapine and/or a pharmaceutically acceptable salt thereof, dibutylhydroxytoluene, an adhesive base agent, and a tackifier, wherein the adhesive base agent is a rubber-based adhesive agent such that a mass ratio of the rubber-based adhesive agent to the tackifier is 1:6 to 1.5:1, and a content of the dibutylhydroxytoluene in the adhesive agent layer is in a range of 0.1% by mass to 3.0% by mass, and a content of the rubber-based adhesive agent in the adhesive agent layer is in a range of 10% by mass to 50% by mass. 2. The patch according to claim 1, wherein the adhesive agent layer further comprises a maleic acid alkali salt. 3. The patch according to claim 2, wherein a content of the maleic acid alkali salt in the adhesive agent layer has is in a range of 0.5% by mass to 15% by mass. 4. The patch according to claim 2, wherein the maleic acid alkali salt is at least one of disodium maleate and monosodium maleate. 5. The patch according to claim 1, wherein the adhesive agent layer includes free asenapine such that a mass ratio of the free asenapine to the rubber-based adhesive agent is 1:17 to 1:1.2. 6. The patch according to claim 5, wherein a content of the rubber-based adhesive agent in the adhesive agent layer is in a range of 12% by mass to 40% by mass. 7. The patch according to claim 5, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber. 8. The patch according to claim 1, wherein the adhesive agent layer further comprises at least one absorption enhancer selected from the group consisting of isostearyl alcohol, capric acid, propylene glycol monolaurate, isopropyl myristate, isopropyl palmitate, lauric acid diethanolamide, propylene glycol, and polyethylene glycol. 9. The patch according to claim 3, wherein the maleic acid alkali salt is at least one of disodium maleate and monosodium maleate. 10. The patch according to claim 1, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber. 11. The patch according to claim 2, wherein the adhesive agent layer includes free asenapine such that a mass ratio of the free asenapine to the rubber-based adhesive agent is 1:17 to 1:1.2. 12. The patch according to claim 11, wherein a content of the rubber-based adhesive agent in the adhesive agent layer is in a range of 12% by mass to 40% by mass. 13. The patch according to claim 11, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber. 14. The patch according to claim 12, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber. 15. The patch according to claim 3, wherein the adhesive agent layer includes free asenapine such that a mass ratio of the free asenapine to the rubber-based adhesive agent is 1:17 to 1:1.2. 16. The patch according to claim 15, wherein a content of the rubber-based adhesive agent in the adhesive agent layer is in a range of 12% by mass to 40% by mass. 17. The patch according to claim 15, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber. 18. The patch according to claim 16, wherein the rubber-based adhesive agent is at least one selected from the group consisting of a styrene-isoprene-styrene block copolymer, polyisobutylene, and a silicone rubber. 19. The patch according to claim 4, wherein the adhesive agent layer includes free asenapine such that a mass ratio of the free asenapine to the rubber-based adhesive agent is 1:17 to 1:1.2. 20. The patch according to claim 1, wherein the adhesive agent layer includes free asenapine such that a content of the free asenapine is in a range of 2% by mass to 10% by mass.