Claims for Patent: 11,191,753

Summary for Patent: 11,191,753

Title:	Liquid pharmaceutical composition
Abstract:	The present invention provides a physically and chemically stable pharmaceutical liquid composition including sodium picosulfate, magnesium oxide, citric acid and malic acid and methods of making and using such a composition.
Inventor(s):	Nam; Bong Gil (Seoul, KR), Lee; Byeung Jun (Anyang-si, KR), Jin; Shunji (Seongnam-si, KR)
Assignee:	FERRING INTERNATIONAL CENTER SA. (St. Prex, CH)
Application Number:	16/847,608
Patent Claims:	1. A method of treatment for cleaning the colon of a subject in need thereof, comprising orally administering to the subject an effective amount of a pharmaceutical composition comprising sodium picosulfate, magnesium oxide, citric acid, and malic acid, wherein the pharmaceutical composition is a solution with a pH in the range from 4.1 to 5.4. 2. The method of claim 1, wherein in the method is for pretreatment for colonoscopy. 3. The method of claim 1, wherein in the method is for pretreatment for surgery. 4. The method of claim 1, wherein in the method is for pretreatment for surgery colon X-ray. 5. The method of claim 1, wherein the sodium picosulfate, the magnesium oxide, the citric acid, and the malic acid are present in a weight ratio of 0.003 to 0.009:1 to 3:3.5 to 10.5:0.01 to 13 (sodium picosulfate:magnesium oxide:citric acid:malic acid). 6. The method of claim 1, wherein the composition further comprises one or more excipients chosen from pH adjusters, stabilizers, preservatives, sweeteners, and fragrance ingredients. 7. The method of claim 1, wherein the composition further comprises acesulfame potassium. 8. The method of claim 1, wherein the composition further comprises disodium edetate. 9. The method of claim 1, wherein the composition further comprises sodium benzoate. 10. The method of claim 1, wherein the composition further comprises sodium hydroxide. 11. The method of claim 1, wherein the composition further comprises sucralose. 12. A method of treatment for cleaning the colon of a subject in need thereof, comprising orally administering to the subject an effective amount of a pharmaceutical composition comprising sodium picosulfate, magnesium oxide, citric acid, and malic acid, wherein the pharmaceutical composition is a liquid with a pH ranging from 4.1 to 5.4, and further wherein the sodium picosulfate, the magnesium oxide, the citric acid, and the malic acid are present in a weight ratio of about 0.005:1.75:6:4.19 (sodium picosulfate:magnesium oxide:citric acid:malic acid). 13. The method of claim 12, wherein in the method is for pretreatment for colonoscopy. 14. The method of claim 12, wherein in the method is for pretreatment for surgery. 15. The method of claim 12, wherein in the method is for pretreatment for surgery colon X-ray. 16. The method of claim 12, wherein the composition further comprises one or more excipients chosen from pH adjusters, stabilizers, preservatives, sweeteners, and fragrance ingredients. 17. The method of claim 12, wherein the composition further comprises acesulfame potassium. 18. The method of claim 12, wherein the composition further comprises disodium edetate. 19. The method of claim 12, wherein the composition further comprises sodium benzoate. 20. The method of claim 12, wherein the composition further comprises sodium hydroxide. 21. The method of claim 12, wherein the composition further comprises sucralose.