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Last Updated: December 23, 2024

Claims for Patent: 11,266,750

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Summary for Patent: 11,266,750

Title:	Methods for making ultrasound contrast agents
Abstract:	Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Inventor(s):	Robinson; Simon P. (Stow, MA), Siegler; Robert W. (Chelmsford, MA), Nguyen; Nhung Tuyet (Westford, MA), Onthank; David C. (Groton, MA), Anklekar; Tarakeshwar Vishwanath (Billerica, MA), Van Kirk; Charles Chester (Beverly, MA)
Assignee:	Lantheus Medical Imaging, Inc. (North Billerica, MA)
Application Number:	17/325,176
Patent Claims:	1. A method of ultrasound contrast imaging a subject comprising selecting an MPEG5000-DPPE having a calcium concentration of less than 115 parts per million (ppm), combining the MPEG5000-DPPE with DPPA, DPPC and propylene glycol, to form a phospholipid solution having a calcium concentration of less than 0.7 ppm, combining the phospholipid solution with an aqueous solution to form a phospholipid suspension, activating the phospholipid suspension with a perfluorocarbon gas to form lipid-encapsulated gas microspheres, administering the lipid-encapsulated gas microspheres to a subject, and obtaining an ultrasound image of the subject. 2. The method of claim 1, wherein DPPA, DPPC and MPEG-5000-DPPE are present in the phospholipid solution in a mole % ratio of 10 to 82 to 8 (10:82:8). 3. The method of claim 1, wherein DPPA has a calcium concentration of less than 780 ppm, DPPC has a calcium concentration of less than 90 ppm, and propylene glycol has a calcium concentration of less than 0.7 ppm. 4. The method of claim 1, wherein the perfluorocarbon gas is perfluoropropane gas. 5. A method of ultrasound contrast imaging a subject comprising selecting an MPEG5000-DPPE having a combined calcium and magnesium concentration of less than 115 parts per million (ppm), combining the MPEG5000-DPPE with DPPA, DPPC and propylene glycol, to form a phospholipid solution having a combined calcium and magnesium concentration of less than 0.7 ppm, combining the phospholipid solution with an aqueous solution to form a phospholipid suspension, activating the phospholipid suspension with a perfluorocarbon gas to form lipid-encapsulated gas microspheres, administering the lipid-encapsulated gas microspheres to a subject, and obtaining an ultrasound image of the subject. 6. The method of claim 5, wherein DPPA, DPPC and MPEG-5000-DPPE are present in the phospholipid solution in a mole % ratio of 10 to 82 to 8 (10:82:8). 7. The method of claim 5, wherein DPPA has a combined calcium and magnesium concentration of less than 780 ppm, DPPC has a combined calcium and magnesium concentration of less than 90 ppm, and propylene glycol has a combined calcium and magnesium concentration of less than 0.7 ppm. 8. The method of claim 5, wherein the perfluorocarbon gas is perfluoropropane gas.

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