Claims for Patent: 11,331,442

Summary for Patent: 11,331,442

Title:	Drug delivery systems and related methods
Abstract:	Systems and methods for isolating and/or desiccating a portion of a drug delivery tract of a drug delivery apparatus to reduce water vapor content therein are provided. For example, there is provided a metered dose inhaler for delivering aerosolized medicament or other matter to a user. The aerosolized medicament or other matter may be discharged from a discharge passageway within the inhaler into an inhalation passageway for inhalation by a user, and the inhaler may comprise a seal member operative to selectively isolate the discharge passageway from the inhalation passageway and external environment during inactivity. The inhaler may further comprise a desiccant material arranged to withdraw moisture from the isolated discharge passageway. In other instances, desiccant material may be arranged to withdraw moisture from the discharge passageway of the inhaler without isolating the discharge passage during inactivity.
Inventor(s):	Ferriter; Matthew (Chapel Hill, NC), Himel; Denny (Cary, NC), Foster; Brian (Apex, NC), King; Michael L. (Durham, NC), Deaton; Dan (New Hill, NC), Hamlin; Fred (Cambridge, GB), Sherwood; Jill (Raleigh, NC), Dwivedi; Sarvajna Kumar (Redwood City, CA), Sheehy, Jr.; Robert V. (N. Attleboro, MA)
Assignee:	Pearl Therapeutics, Inc. (Redwood City, CA)
Application Number:	17/487,997
Patent Claims:	1. A drug delivery device comprising: a canister containing a drug formulation and having a discharge valve and a valve stem defining a valve stem passage through which the drug formulation is selectively discharged; a base housing including an inhalation passageway through which the drug formulation is discharged during an inhalation event; a valve stem block including a discharge orifice in fluid communication with the inhalation passageway from which the drug formulation is ejected during the inhalation event after passing through the valve stem passage; a desiccant housing attached to the canister with the valve stem extending through the desiccant housing; a desiccant material provided in the desiccant housing in fluid communication with the valve stem passage; wherein the canister, the desiccant housing and the desiccant material form a cartridge that is removably installable in the base housing with the valve stem of the canister engaging the valve stem block when the cartridge is installed; and wherein, when the cartridge is installed, the desiccant material extends from a location above the discharge orifice of the valve stem block to a location below the discharge orifice. 2. The drug delivery device of claim 1 wherein the valve stem of the canister includes an aperture in a side thereof, and wherein, when the valve stem is in an expanded position, the valve stem passage is in fluid communication with the desiccant material via the aperture in the side of the valve stem. 3. The drug delivery device of claim 1 wherein the canister is removably installable in the desiccant housing and a canister seal is positioned between the desiccant housing and the canister to assist in at least partially isolating the desiccant material from an external environment of the drug delivery device. 4. The drug delivery device of claim 1 wherein the desiccant housing includes a stem seal formed integrally therewith through which the valve stem extends, the stem seal assisting in at least partially isolating the desiccant material from an external environment of the drug delivery device. 5. The drug delivery device of claim 1 wherein the desiccant material is an annular or semi-annular molded component. 6. The drug delivery device of claim 1 wherein the desiccant material is a semi-annular molded component, which partially encircles the valve stem and extends beyond a terminal end of the valve stem. 7. The drug delivery device of claim 1 wherein the desiccant housing and the desiccant material are correspondingly shaped, and wherein each of the desiccant housing and the desiccant material extend beyond a terminal end of the valve stem. 8. The drug delivery device of claim 1 wherein, apart from when the valve stem is depressed, the desiccant material is arranged to continuously remove moisture at least from the valve stem passage defined by the valve stem throughout the usable life of the drug formulation contained in the canister. 9. The drug delivery device of claim 1 wherein, when the valve stem of the canister is fully depressed, the desiccant material is isolated from the valve stem passage and an external environment of the drug delivery device. 10. The drug delivery device of claim 1, further comprising: a mouthpiece aperture in fluid communication with the inhalation passageway through which the drug formulation is discharged during the inhalation event; and a desiccant chamber within the desiccant housing in which the desiccant material is contained, the desiccant chamber being in fluid communication with the valve stem passage at least when the drug delivery device is in a storage configuration. 11. The drug delivery device of claim 10, wherein the desiccant housing and the canister collectively define the desiccant chamber within which the desiccant material is contained. 12. The drug delivery device of claim 1, wherein the drug delivery device is a metered dose inhaler. 13. The drug delivery device of claim 12, wherein the drug formulation comprises a medicament suitable for use in bronchodilation therapy. 14. The drug delivery device of claim 10, wherein the drug delivery device is a metered dose inhaler. 15. The drug delivery device of claim 14, wherein the drug formulation comprises a medicament suitable for bronchodilation therapy.