Claims for Patent: 11,492,353

Summary for Patent: 11,492,353

Title:	Paramyxoviridae
Abstract:	Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I:
Inventor(s):	Mackman Richard L., Parrish Jay P., Ray Adrian S., Theodore Dorothy Agnes
Assignee:	Gilead Sciences, Inc.
Application Number:	US16879491
Patent Claims:	3. The compound of claim 2 , wherein R is selected from the group consisting of methyl claim 2 , ethyl claim 2 , n-propyl claim 2 , i-propyl claim 2 , 1-butyl claim 2 , 2-methyl-1-propyl claim 2 , 2-butyl claim 2 , 2-methyl-2-propyl claim 2 , 2-pentyl claim 2 , 3-pentyl claim 2 , 2-methyl-2-butyl claim 2 , 3-methyl-2-butyl claim 2 , 3-methyl-1-butyl claim 2 , and 2-methyl-1-butyl.4. The compound of claim 1 , wherein Rand Rare each OH.5. The compound of claim 4 , wherein Ris —(C═O)—(C-C)alkyl; wherein the (C-C)alkyl of Ris selected from the group consisting of methyl claim 4 , ethyl claim 4 , n-propyl claim 4 , i-propyl claim 4 , 1-butyl claim 4 , 2-methyl-1-propyl claim 4 , 2-butyl claim 4 , 2-methyl-2-propyl claim 4 , 2-pentyl claim 4 , 3-pentyl claim 4 , 2-methyl-2-butyl claim 4 , 3-methyl-2-butyl claim 4 , 3-methyl-1-butyl claim 4 , and 2-methyl-1-butyl claim 4 , each of which is optionally substituted by NH.6. The compound of claim 5 , wherein Ris —(C═O)—CH(CH).7. The compound of claim 5 , wherein Ris —(C═O)—CH(NH)CH(CH).8. The compound of claim 1 , wherein Rand Rare each —O(C═O)(C-C)alkyl claim 1 , wherein the (C-C)alkyl groups of Rand Rare each optionally substituted with NH.9. The compound of claim 8 , wherein the (C-C)alkyl groups of Rand Rare each selected from the group consisting of methyl claim 8 , ethyl claim 8 , n-propyl claim 8 , i-propyl claim 8 , 1-butyl claim 8 , 2-methyl-1-propyl claim 8 , 2-butyl claim 8 , 2-methyl-2-propyl claim 8 , 2-pentyl claim 8 , 3-pentyl claim 8 , 2-methyl-2-butyl claim 8 , 3-methyl-2-butyl claim 8 , 3-methyl-1-butyl claim 8 , and 2-methyl-1-butyl claim 8 , each of which is optionally substituted with NH.10. The compound of claim 9 , wherein each of Rand Ris selected from the group consisting of —O(C═O)—CH(CH)and —O(C═O)—CH(NH)CH(CH).11. The compound of claim 10 , wherein Rand Rare —O(C═O)—CH(NH)CH(CH)and —O(C═O)—CH(CH) claim 10 , respectively; —O(C═O)—CH(CH)and —O(C═O)—CH(NH)CH(CH) claim 10 , respectively; or —O(C═O)—CH(NH)CH(CH)and —O(C═O)—CH(NH)CH(CH) claim 10 , respectively.12. The compound of claim 10 , wherein Rand Rare each —O(C═O)—CH(CH).13. The compound of claim 8 , wherein Ris —(C═O)—(C-C)alkyl claim 8 , wherein the (C-C)alkyl of Ris optionally substituted by NH.14. The compound of claim 13 , wherein the (C-C)alkyl of Ris selected from the group consisting of methyl claim 13 , ethyl claim 13 , n-propyl claim 13 , i-propyl claim 13 , 1-butyl claim 13 , 2-methyl-1-propyl claim 13 , 2-butyl claim 13 , 2-methyl-2-propyl claim 13 , 2-pentyl claim 13 , 3-pentyl claim 13 , 2-methyl-2-butyl claim 13 , 3-methyl-2-butyl claim 13 , 3-methyl-1-butyl claim 13 , and 2-methyl-1-butyl claim 13 , each of which is optionally substituted by NH.15. The compound of claim 14 , wherein Ris —(C═O)—CH(CH).16. The compound of claim 14 , wherein Ris —(C═O)—CH(NH)CH(CH).17. The compound of claim 8 , wherein Ris —O(C═O)—CH(CH) claim 8 , Ris —O(C═O)—CH(CH) claim 8 , and Ris —(C═O)—CH(CH).18. The compound of claim 1 , wherein Ris OH and Ris —O(C═O)(C-C)alkyl claim 1 , wherein the (C-C)alkyl of Ris optionally substituted by NH.19. The compound of claim 18 , wherein the (C-C)alkyl of Ris selected from the group consisting of methyl claim 18 , ethyl claim 18 , n-propyl claim 18 , i-propyl claim 18 , 1-butyl claim 18 , 2-methyl-1-propyl claim 18 , 2-butyl claim 18 , 2-methyl-2-propyl claim 18 , 2-pentyl claim 18 , 3-pentyl claim 18 , 2-methyl-2-butyl claim 18 , 3-methyl-2-butyl claim 18 , 3-methyl-1-butyl claim 18 , and 2-methyl-1-butyl claim 18 , each of which is optionally substituted by NH.20. The compound of claim 19 , wherein Ris —O(C═O)—CH(CH).21. The compound of claim 19 , wherein Ris —O(C═O)—CH(NH)CH(CH).22. The compound of claim 18 , wherein Ris —(C═O)—(C-C)alkyl; wherein the (C-C)alkyl of Ris selected from the group consisting of methyl claim 18 , ethyl claim 18 , n-propyl claim 18 , i-propyl claim 18 , 1-butyl claim 18 , 2-methyl-1-propyl claim 18 , 2-butyl claim 18 , 2-methyl-2-propyl claim 18 , 2-pentyl claim 18 , 3-pentyl claim 18 , 2-methyl-2-butyl claim 18 , 3-methyl-2-butyl claim 18 , 3-methyl-1-butyl claim 18 , and 2-methyl-1-butyl claim 18 , each of which is optionally substituted by NH.23. The compound of claim 22 , wherein Ris —(C═O)—CH(CH).24. The compound of claim 22 , wherein Ris —(C═O)—CH(NH)CH(CH).25. The compound of claim 1 , wherein Ris OH and Ris —O(C═O)(C-C)alkyl claim 1 , wherein the (C-C)alkyl of Ris optionally substituted by NH.26. The compound of claim 25 , wherein the (C-C)alkyl of Ris selected from the group consisting of methyl claim 25 , ethyl claim 25 , n-propyl claim 25 , i-propyl claim 25 , or 1-butyl claim 25 , 2-methyl-1-propyl claim 25 , 2-butyl claim 25 , 2-methyl-2-propyl claim 25 , 2-pentyl claim 25 , 3-pentyl claim 25 , 2-methyl-2-butyl claim 25 , 3-methyl-2-butyl claim 25 , 3-methyl-1-butyl claim 25 , and 2-methyl-1-butyl claim 25 , each of which is optionally substituted by NH.27. The compound of claim 26 , wherein Ris —O(C═O)—CH(CH).28. The compound of claim 26 , wherein Ris —O(C═O)—CH(NH)CH(CH).29. The compound of claim 25 , wherein Ris —(C═O)—(C-C)alkyl; wherein the (C-C)alkyl of Ris selected from the group consisting of methyl claim 25 , ethyl claim 25 , n-propyl claim 25 , i-propyl claim 25 , 1-butyl claim 25 , 2-methyl-1-propyl claim 25 , 2-butyl claim 25 , 2-methyl-2-propyl claim 25 , 2-pentyl claim 25 , 3-pentyl claim 25 , 2-methyl-2-butyl claim 25 , 3-methyl-2-butyl claim 25 , 3-methyl-1-butyl claim 25 , and 2-methyl-1-butyl claim 25 , each of which is optionally substituted by NH.30. The compound of claim 29 , wherein Ris —(C═O)—CH(CH).31. The compound of claim 29 , wherein Ris —(C═O)—CH(NH)CH(CH).32. The compound of claim 1 , wherein Rand Rare each —O(C═O)(C-C)alkyl.33. The compound of claim 32 , wherein the (C-C)alkyl groups of Rand Rare each selected from the group consisting of methyl claim 32 , ethyl claim 32 , n-propyl claim 32 , i-propyl claim 32 , 1-butyl claim 32 , 2-methyl-1-propyl claim 32 , 2-butyl claim 32 , 2-methyl-2-propyl claim 32 , 2-pentyl claim 32 , 3-pentyl claim 32 , 2-methyl-2-butyl claim 32 , 3-methyl-2-butyl claim 32 , 3-methyl-1-butyl claim 32 , and 2-methyl-1-butyl.34. The compound of claim 32 , wherein Ris —(C═O)—(C-C)alkyl.35. The compound of claim 34 , wherein the (C-C)alkyl of Ris selected from the group consisting of methyl claim 34 , ethyl claim 34 , n-propyl claim 34 , i-propyl claim 34 , 1-butyl claim 34 , 2-methyl-1-propyl claim 34 , 2-butyl claim 34 , 2-methyl-2-propyl claim 34 , 2-pentyl claim 34 , 3-pentyl claim 34 , 2-methyl-2-butyl claim 34 , 3-methyl-2-butyl claim 34 , 3-methyl-1-butyl claim 34 , and 2-methyl-1-butyl.36. The compound of claim 4 , wherein Ris —(C═O)—(C-C)alkyl.37. The compound of claim 36 , wherein the (C-C)alkyl of Ris selected from the group consisting of methyl claim 36 , ethyl claim 36 , n-propyl claim 36 , i-propyl claim 36 , 1-butyl claim 36 , 2-methyl-1-propyl claim 36 , 2-butyl claim 36 , 2-methyl-2-propyl claim 36 , 2-pentyl claim 36 , 3-pentyl claim 36 , 2-methyl-2-butyl claim 36 , 3-methyl-2-butyl claim 36 , 3-methyl-1-butyl claim 36 , and 2-methyl-1-butyl.