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Last Updated: January 8, 2025

Claims for Patent: 11,672,938


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Summary for Patent: 11,672,938
Title:Start-up protocols for nitric oxide delivery device
Abstract:Start-up protocols for a device and method for administering NO is described.
Inventor(s):David H. Fine, Edward Bromberg, Ryan Denton, Jason White, Lucas G. Gamero, Bryan Johnson, Gregory Vasquez, Doug Sonosky
Assignee:Vero Biotech Inc
Application Number:US16/513,312
Patent Claims: 1. A method, comprising: coupling a cassette configured to provide NO gas to a console containing a pump and a first flow sensor, the cassette coupled to the console such that the first flow sensor is disposed between the cassette and the pump; closing an output solenoid that is disposed after the cassette, the output solenoid, when open, configured to allow gas, including NO gas, to be conveyed to a patient, closing the output solenoid configured to place the cassette in fluid communication with a second flow sensor disposed between the cassette and an exhaust port; activating the pump; and leak testing the cassette by comparing a flow rate measured by the first flow sensor to a flow rate measured by a second flow sensor.

2. The method of claim 1, further comprising: removing the cassette; and operating the pump after removing the cassette to flush the first flow sensor and the second flow sensor.

3. The method of claim 1, further comprising: opening the outlet solenoid; operating the pump to produce a flow of gas that passes through a gas accumulator and a restrictor to abate pressure pulses; and delivering the gas, including NO gas, to the patient after opening the outlet solenoid.

4. The method of claim 1, further comprising: closing a proportional valve disposed between the cassette and the second flow sensor; operating the pump to increase a pressure in the cassette; once the pressure in the cassette reaches a threshold, turning off the pump; and pressure testing a seal between the cassette and the console by measuring a rate at which the pressure in the cassette decreases after turning off the pump.

5. A device, comprising: a vessel containing liquid N2O4; a heater configured to heat the vessel and the liquid N2O4 contained therein to produce NO2 gas; a liquid N2O4 monitor operatively coupled to the heater and configured to monitor at least one of the current or the voltage applied to the heater, the liquid N2O4 monitor configured to determine when the liquid N2O4 in the vessel has been depleted and only NO2 gas remains based on at least one of a current or a voltage drawn by the heater; and a leak detector configured to identify a leak based on voltage drawn by a valve in the device.

6. The device of claim 5, wherein the liquid N2O4 monitor is configured to monitor a temperature of the vessel containing liquid N2O4.

7. The device of claim 5, further comprising a NO availability gauge that displays output from the liquid N2O4 monitor.

8. The device of claim 7, wherein the NO availability gauge is configured to alert a user to replace a cassette that includes the vessel based on a time and temperature history of the vessel.

9. The device of claim 5, further comprising an NO dosing display in micrograms per minute or parts per million.

10. The device of claim 9, wherein the NO dosing display is corrected for formation of NO2.

11. The device of claim 10, wherein the NO dosing display is corrected by varying one or more of an amount of O2 in a sample, a length of the sampling lines, or a volumetric flow rate in the sampling lines.

12. The device of claim 5, further comprising: at least one of a leak or blockage detector, the at least one of the leak or blockage detector configured to monitor one or more of a change in the size and frequency of pressure pulses in an output line.

13. A method, comprising coupling a NO source cassette that includes (i) liquid N2O4 and is configured to produce NO2 gas and (ii) a conversion cartridge configured to convert the NO2 gas to provide NO gas to a console such that the NO source cassette is configured to receive air from a pump via an input and provide NO gas via an output; closing a solenoid between the output of the NO source cassette and a patient interface to isolate the NO source cassette from an exterior of the console; operating a pump to increase a pressure in the NO source cassette; once the pressure in the NO source cassette reaches a threshold, turning off the pump; and pressure testing a seal between the NO source cassette and the console by measuring a rate at which the pressure in the NO source cassette decreases after turning off the pump.

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