You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: December 23, 2024

Claims for Patent: 4,894,445


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 4,894,445
Title: Metal-isonitrile adducts for preparing radionuclide complexes
Abstract:A method for preparing a coordination complex of an isonitrile ligand and a radioisotope of Tc, Ru, Co, Pt, Re, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Nb and Ta from a non-radioactive metal adduct of the isonitrile.
Inventor(s): Carpenter, Jr.; Alan P. (Tyngsboro, MA), Maheu; Leo J. (Andover, MA), Patz; Michael A. (Somerville, MA), Tulip; Thomas H. (Nashua, NH), Linder; Karen E. (Somerville, MA), Subramanyam; Vinayakam (Towson, MD), Thompson; Jeffery S. (Wilmington, DE)
Assignee: E. I. Du Pont De Nemours and Company (Wilmington, DE)
Application Number:06/880,349
Patent Claims: 1. A method for preparing a coordination complex of an isonitrile ligand and a radioactive metal selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta, said method comprising admixing a lyophilized soluble copper adduct of said isonitrile ligand with a radioactive metal in a suitable solvent to replace said copper with the radioactive metal thereby forming said coordination complex.

2. The method of claim 1 wherein said radioactive metal is Tc.

3. The method of claim 2 wherein said radioactive metal is Tc-99m.

4. The method of claim 3 wherein the isonitrile ligand has the formula CNR where R is butyl.

5. The method of claim 3 wherein the isonitrile ligand has the formula CNR where R is butyl having an alkyl ether or alkyl ester substitution.

6. The method of claim 1 wherein the copper adduct of said isonitrile ligand has the formula [Cu(CNR).sub.2 Y]X wherein R is a suitable organic radical, X is an appropriate counter ion and Y is a bidentate chelating ligand.

7. The method of claim 6 wherein Y is selected from the group consisting of phenanthroline, substituted phenanthroline, diimine, substituted diimine, bipyridine or substituted bipyridine.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.