Claims for Patent: 6,310,101

Summary for Patent: 6,310,101

Title:	Treatments using venlafaxine
Abstract:	This invention provides a method of treating obesity, generalized anxiety disorder, post-traumatic stress disorder, late luteal phase disphoric disorder (premenstrual syndrome), attention deficit disorder, with and without hyperactivity, Gilles de la Tourette syndrome, bulimia nervosa or Shy Drager Syndrome in a mammal by administering to the mammal an effective amount of a hydroxycycloalkanephenethyl amine of the following structural formula: ##STR1## in which A is a moiety of the formula ##STR2## where the dotted line represents optional unsaturation; R.sub.1 is hydrogen or alkyl; R.sub.2 is alkyl; R.sub.4 is hydrogen, alkyl, formyl, or alkanol; R.sub.5 and R.sub.6 are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy; R.sub.7 is hydrogen or alkyl; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.
Inventor(s):	Rudolph; Richard L. (Berwyn, PA), Derivan; Albert T. (Villanova, PA), Muth; Eric A. (New Hope, PA), Upton; G. Virginia (Radnor, PA)
Assignee:	American Home Products Corporation (Madison, NJ)
Application Number:	09/285,812
Patent Claims:	1. A method of treating panic disorder, in a mammal suffering from panic disorder, comprising administering to the mammal an effective amount of a compound of the formula: ##STR6## in which A is a moiety of the formula ##STR7## wherein the dotted line represents optional unsaturation; R1 is hydrogen or alkyl of 1 to 6 carbon atoms; R.sub.2 is alkyl of 1 to 6 carbon atoms; R.sub.4 is hydrogen, alkyl of 1 to 6 carbon atoms, formyl, or alkanol of 2 to 7 carbon atoms; R.sub.5 and R.sub.6 are, independently, hydrogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 7 carbon atoms, cyano, nitro, alkylmercapto of 1 to 6 carbon atoms, amino, alkylamino of 1 to 6 carbon atoms, dialkylamino in which each alkyl group is of 1 to 6 carbon atoms, alkanamido of 2 to 7 carbon atoms, halo, trifluoromethyl, or taken together, methylene dioxy; R.sub.7 is hydrogen or alkyl of 1 to 6 carbon atoms; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof. 2. The method of claim 1 wherein the compound is: ##STR8## in which A is a moiety of the formula ##STR9## wherein the dotted line represents optional unsaturation, and R.sub.1 is hydrogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is alkyl of 1 to 3 carbon atoms; R.sub.5 is hydrogen, hydroxyl, alkoxy of 1 to 3 carbon atoms, chloro, bromo, trifuoromethyl or alkyl of 1 to 3 carbon atoms; R.sub.6 is alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, chloro, bromo, trifluoromethyl or alkanoyloxy of 2 to 3 carbon atoms; R.sub.7 is hydrogen or alkyl of 1 to 3 carbon atoms; or a pharmaceutically acceptable salt thereof. 3. The method of claim 2 wherein R.sub.5 and R.sub.6 are both in the meta positions or one of R.sub.5 or R.sub.6 is in the para position and n is 2. 4. The method of claim 2 wherein the compound is 1-[(2-dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol or a pharmaceutically acceptable salt thereof. 5. The method of claim 2 wherein the compound is 1-[2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol or a pharmaceutically acceptable salt thereof. 6. The method of claim 1 wherein the effective amount comprises a daily dose of between about 50 mg/day and about 375 mg/day. 7. The method of claim 4 wherein the effective amount comprises a daily dose of between about 75 mg/day and about 200 mg/day. 8. A method of treating panic disorder in a human, comprising administering to the human in need thereof an effective amount of a compound of the formula: ##STR10## in which A is a moiety of the formula ##STR11## wherein the dotted line represents optional unsaturation; R1 is hydrogen or alkyl of 1 to 6 carbon atoms; R.sub.2 is alkyl of 1 to 6 carbon atoms; R.sub.4 is hydrogen, alkyl of 1 to 6 carbon atoms, formyl, or alkanol of 2 to 7 carbon atoms; R.sub.5 and R.sub.6 are, independently, hydrogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 7 carbon atoms, cyano, nitro, alkylmercapto of 1 to 6 carbon atoms, amino, alkylamino of 1 to 6 carbon atoms, dialkylamino in which each alkyl group is of 1 to 6 carbon atoms, alkanamido of 2 to 7 carbon atoms, halo, trifluoromethyl, or taken together, methylene dioxy; R.sub.7 is hydrogen or alkyl of 1 to 6 carbon atoms; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof. 9. A method of treating panic disorder in a human, the method comprising administering to a human in need thereof a pharmaceutical composition comprising an effective amount of a compound of the formula: ##STR12## in which A is a moiety of the formula ##STR13## wherein the dotted line represents optional unsaturation; R1 is hydrogen or alkyl of 1 to 6 carbon atoms; R.sub.2 is alkyl of 1 to 6 carbon atoms; R.sub.4 is hydrogen, alkyl of 1 to 6 carbon atoms, formyl, or alkanol of 2 to 7 carbon atoms; R.sub.5 and R.sub.6 are, independently, hydrogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 7 carbon atoms, cyano, nitro, alkylmercapto of 1 to 6 carbon atoms, amino, alkylamino of 1 to 6 carbon atoms, dialkylamino in which each alkyl group is of 1 to 6 carbon atoms, alkanamido of 2 to 7 carbon atoms, halo, trifluoromethyl, or taken together, methylene dioxy; R.sub.7 is hydrogen or alkyl of 1 to 6 carbon atoms; and n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof, and a carrier. 10. The method of claim 8 comprising administering to a human in need thereof an effective amount of the compound 1-[(2-dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol or a pharmaceutically acceptable salt thereof. 11. The method of claim 9 comprising administering to a human in need thereof a pharmaceutical composition containing an effective amount of 1-[(2-dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol or a pharmaceutically acceptable salt thereof and a carrier. 12. The method of claim 8 wherein the effective amount comprises a daily dose of between about 50 mg/day to about 375 mg/day. 13. The method of claim 8 wherein the effective amount comprises a daily dose of about 75 mg/day to about 200 mg/day. 14. The method of claim 9 wherein the effective amount comprises a daily dose of between about 50 mg/day to about 375 mg/day. 15. The method of claim 9 wherein the effective amount comprises a daily dose of about 75 mg/day to about 200 mg/day. 16. The method of claim 8 comprising administering orally to a human in need thereof an effective amount of the compound 1-[(2-dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol or a pharmaceutically acceptable salt thereof. 17. The method of claim 9 comprising administering orally to a human in need thereof a pharmaceutical composition containing an effective amount of 1-[(2-dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol or a pharmaceutically acceptable salt thereof and a carrier. 18. The method of claim 9 wherein the pharmaceutical composition is in tablet form. 19. The method of claim 9 wherein the pharmaceutical composition is in capsule form.