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Last Updated: December 22, 2024

Claims for Patent: 6,339,105

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Summary for Patent: 6,339,105

Title:	Analgesic regimen
Abstract:	A regimen for the administration of tramadol for the treatment of analgesia is described. The regimen involves a slower initial titration rate of tramadol which results in a significantly lower percentage of discontinuations of therapy due to a lower incidence and severity of side effects.
Inventor(s):	Kamin; Marc (West Windsor, NJ), Olson; William (Princeton, NJ)
Assignee:	Ortho-McNeil Pharmaceutical, Inc. (Raritan, NJ)
Application Number:	09/415,753
Patent Claims:	1. A regimen for the treatment of pain which comprises administering to one in need thereof about 25 mg of tramadol on days 1-3; about 50 mg of tramadol on days 4-6; about 75 mg of tramadol on days 7-9; about 100 mg of tramadol on days 10-12; about 150 mg of tramadol on days 13-15; and about 200 mg of tramadol on days 16-28 and thereafter, in the form of a pharmaceutical composition containing tramadol as the active ingredient; whereby discontinuations due to adverse side effects are reduced. 2. A regimen for the treatment of pain according to claim 1 which comprises administering to one in need thereof about 25 mg of tramadol on days 1-3; about 50 mg of tramadol on days 4-6; about 75 mg of tramadol on days 7-9; about 100 mg of tramadol on days 10-12; about 150 mg of tramadol on days 13-15; and about 200 mg of tramadol on day 16 and thereafter, in the form of a pharmaceutical composition containing tramadol as the active ingredient; whereby discontinuations due to adverse side effects are reduced. 3. A regimen for the treatment of pain according to claim 1 which comprises administering to one in need thereof about 25 mg of tramadol q.d. on days 1-3, about 25 of mg of tramadol b.i.d. on days 4-6, about 25 mg of trainadol t.i.d. on days 7-9, about 25 mg of tramadol q.i.d. on days 10-12, and about 50 mg of tramadol t.i.d. on days 13-28 in the form of a pharmaceutical composition containing tramadol as the active ingredient; whereby discontinuations due to adverse side effects are reduced. 4. The method according to any of claims 1, 2, or 3 in which tramadol is administered in the form of tramadol hydrochloride.

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