Claims for Patent: 7,250,419

Summary for Patent: 7,250,419

Title:	Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition
Abstract:	The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
Inventor(s):	Hardern; David (Sutton Bonington, GB), Ingall; Anthony (Loughborough, GB), Springthorpe; Brian (Loughborough, GB), Willis; Paul (West Bridgford, GB), Guile; Simon (Loughborough, GB)
Assignee:	AstraZeneca AB (Sodertalje, SE)
Application Number:	11/230,493
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 7,250,419
Patent Claims:	1. A compound selected from the group consisting of [1S-(1.alpha.,2.alpha.,3.beta.(1S*,2R*),5.beta.)]-3-[7-[2-(3,4-difluoroph- enyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3- -yl)-5-(2-hydroxyethoxy)-cyclopentane-1,2-diol, and pharmaceutically acceptable salts thereof. 2. The compound 1S-(1.alpha.,2.alpha.,3.beta.(1S*,2R*),5.beta.)]-3-[7-2-(3,4-difluorophen- yl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-y- l)-5-(2-hydroxyethoxy)-cyclopentane-1,2-diol. 3. A pharmaceutical composition comprising a compound as claimed in claim 1 in combination with a pharmaceutically acceptable diluent, adjuvant and/or carrier. 4. A pharmaceutical composition comprising a compound as claimed in claim 2 in combination with a pharmaceutically acceptable diluent, adjuvant and/or carrier. 5. A method of treatment of myocardial infarction which comprises administering to a person suffering therefrom a therapeutically effective amount of a compound according to claim 1. 6. A method of treatment of myocardial infarction which comprises administering to a person suffering therefrom a therapeutically effective amount of a compound according to claim 2. 7. A method of treatment of thrombotic stroke which comprises administering to a person suffering therefrom a therapeutically effective amount of a compound according to claim 1. 8. A method of treatment of thrombotic stroke which comprises administering to a person suffering therefrom a therapeutically effective amount of a compound according to claim 2. 9. A method of treatment of transient ischaemic attacks which comprises administering to a person suffering therefrom a therapeutically effective amount of a compound according to claim 1. 10. A method of treatment of transient ischaemic attacks which comprises administering to a person suffering therefrom a therapeutically effective amount of a compound according to claim 2. 11. A method of treatment of stable and unstable angina which comprises administering to a person suffering therefrom a therapeutically effective amount of a compound according to claim 1. 12. A method of treatment of stable and unstable angina which comprises administering to a person suffering therefrom a therapeutically effective amount of a compound according to claim 2. 13. A method of inhibiting platelet aggregation in a person which comprises administering a therapeutically effective amount of a compound according to claim 1 to said person. 14. A method of inhibiting platelet aggregation in a person which comprises administering a therapeutically effective amount of a compound according to claim 2 to said person.