Claims for Patent: 8,534,281

Summary for Patent: 8,534,281

Title:	Manifold for use in medicament dispenser
Abstract:	A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack comprises a body, the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from said chimney inlet to the chimney exit; the body further defining a chamber having a chamber inlet and a chamber exit, wherein the chimney exit and the chamber inlet lie side-by-side each other such that when the open blister pocket of the blister pack is positioned adjacent thereto the airflow is directed from the chimney exit to the chamber inlet via the open blister pocket to entrain the medicament powder and enable transport thereof in the airflow from the chamber inlet to the chamber exit, and wherein one or more bleed holes are provided between the chimney and the chamber such that bleed airflow is able to be directed into the chamber to disruptively impact the airflow that transports the entrained medicament powder.
Inventor(s):	Davies; Michael Birsha (Ware, GB), Hailey; Mark Andrew (Ware, GB), Palmer; Mark Gregory (Ware, GB), Walker; Richard Ian (Ware, GB)
Assignee:	Glaxo Group Limited (Greenforo, Middlesex, GB)
Application Number:	12/096,820
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,534,281
Patent Claims:	1. A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of each of plural blister packs, the manifold comprising a body, said body defining a chimney having only a single chimney inlet and plural chimney exits for directing airflow from said chimney inlet to said chimney exits; the body further defining a chamber having plural chamber inlets and a chamber exit, wherein the chimney exits and chamber inlets are arranged to form plural pairings of chimney exit and chamber inlet, each said pairing in use associated with an open blister pocket of a different one of said plural blister packs; wherein the chimney exit and chamber inlet of the plural pairings lie side-by-side each other such that when said open blister pocket of the associated blister packs are positioned adjacent thereto said airflow is directed from chimney exit to chamber inlet via the associated open blister pockets to entrain said medicament powder and enable transport thereof in the airflow from the chamber inlet to said chamber exit, and wherein one or more bleed holes are provided between the chimney and the chamber such that bleed airflow is able to be directed into the chamber to disruptively impact the airflow that transports the entrained medicament powder. 2. The manifold according to claim 1, wherein the manifold is arranged such that in use, from 3 to 50% of the total airflow entering the manifold through the chimney inlet is directed via plural chimney exit towards an open blister pocket and from 50% to 97% of the total airflow is directed through the one or more bleed holes into the chamber. 3. The manifold according to claim 2, wherein the manifold is arranged such that in use, from 5 to 25% of the total airflow entering the manifold through the chimney inlet is directed via plural chimney exit towards an open blister pocket and from 95 to 75% of the total airflow is directed through the one or more bleed holes into the chamber. 4. The manifold according to claim 1, wherein the manifold provides an airflow resistance of from 1 to 5 kPa for a total airflow entering the manifold through the chimney inlet at a rate of 60 liters/minute. 5. The manifold according to claim 1, wherein at least one chimney exit defines an essentially circular profile. 6. The manifold according to claim 1 wherein at least one chimney exit is provided with a cross-piece spanning it. 7. The manifold according to claim 6, wherein said cross-piece is cruciform in shape. 8. The manifold according to claim 1, wherein the chimney and the chamber are positioned side-by-side each other. 9. The manifold according to claim 1, wherein the chimney and the chamber are positioned one on top of each other. 10. The manifold according to claim 1, wherein the chimney and the chamber share a common wall and at least one of the one or more bleed holes are provided to said common wall. 11. The manifold according to claim 10, wherein all of the one or more bleed holes are provided to said common wall. 12. The manifold according to claim 1, wherein the one or more bleed holes have a total cross-sectional area of from 1 to 35 mm.sup.2. 13. The manifold according to claim 1, wherein the one or more bleed holes define a profile selected from the group consisting of ovular, circular, D-shaped and elongate slot profiles. 14. The manifold according to claim 13, wherein the one or more bleed holes define an elongate slot profile and each has a length of from 1 to 20 mm and a width of from 0.5 to 3 mm. 15. The manifold according to claim 1, comprising two elongate slot form bleed holes arranged parallel to each other. 16. The manifold according to claim 1, wherein the one or more bleed holes are spaced from the chimney exit. 17. The manifold according to claim 16, wherein the spacing of the one or more bleed holes from the chamber inlet amounts to at least 10% of the length of the chamber measured from the chamber inlet to the chamber exit. 18. The manifold according to claim 1, wherein at least one of the one or more bleed holes is directed towards an inner wall of the chamber. 19. The manifold according to claim 1, wherein the manifold is made from high-density polyethylene. 20. The manifold according to claim 1, wherein the manifold is wholly or partly comprised of and/or coated with a fluoropolymer material. 21. The manifold according to claim 20, wherein said fluoropolymer material comprises multiples of one or more monomeric units selected from the group consisting of tetrafluoroethylene (PTFE), fluorinated ethylene propylene (FEP), perfluoroalkoxyalkane (PFA), ethylene tetrafluoroethylene (ETFE), vinyldienefluoride (PVDF), chlorinated ethylene tetrafluoroethylene and any mixtures thereof. 22. The manifold according to claim 1, wherein the chimney and the chamber are oriented generally perpendicularly to each other. 23. The manifold according to claim 1, wherein the airflow (entraining airflow) and the bleed airflow are respective airflow portions of an inhalation airflow which is drawn into the manifold through the chimney inlet when an inhalation force is applied at the chamber exit. 24. The manifold according to claim 1 adapted such that on application of an inhalation force at the chamber exit, the bleed airflow is greater than the entraining airflow. 25. The manifold according to claim 1, wherein the only air entry points into the chamber are the one or more chamber inlet(s), the one or more bleed holes and the chamber exit. 26. The manifold according to claim 1, wherein the only air entry points into the chimney are the chimney inlet, the one or more bleed holes and the one or more chimney exits. 27. The manifold according to claim 1 which is a one-piece article. 28. The manifold according to claim 1 which is a moulded article. 29. A sub-assembly comprising a manifold according to claim 1 and a mouthpiece fitted thereto to be in communication with the chamber exit such that inhalation at the mouthpiece directs airflow into the manifold through the chimney inlet. 30. The assembly according to claim 29, wherein the mouthpiece is releasably fitted to the manifold. 31. The assembly according to claim 29 wherein the manifold and mouthpiece are in snap-fit engagement. 32. A medicament dispenser device, comprising a manifold according to claim 1, the medicament dispenser device suitable for the delivery of medicament powder from at least one blister pack having at least one blister pocket. 33. The medicament dispenser device according to claim 32 additionally comprising a mouthpiece provided to said manifold. 34. The medicament dispenser device according to claim 33, wherein the manifold locates within a housing at a position intermediate between said mouthpiece and a station for presenting an open blister pocket of said at least one blister pack thereto. 35. The medicament dispenser device according to claim 32, further comprising a housing and, within said housing, a mechanism for opening the or each blister pocket of the at least one blister pack and presenting the or each opened blister pocket to the chimney exit(s) and chamber inlet(s). 36. The medicament dispenser device according to claim 32, wherein said mechanism comprises an indexer for indexing the blister pockets, one at a time, to the manifold. 37. The medicament dispenser device according to claim 36 for use with at least one blister pack in the form of an elongate strip and having multiple distinct pockets for containing distinct medicament doses, wherein said pockets are spaced in series along the length of the strip. 38. The medicament dispenser device according to claim 32, wherein the dispenser device is suitable for the simultaneous delivery of medicament powder from an open blister pocket of each of plural blister packs. 39. The medicament dispenser device according to claim 32 comprising at least one blister pack containing medicament in powder form. 40. The medicament dispenser device according to claim 39, wherein said at least one blister pack comprises plural medicament powder-containing blisters. 41. The medicament dispenser device according to claim 39 wherein said at least one blister pack comprises plural medicament powder containing blisters arranged in series fashion on an elongate strip-form blister pack. 42. The medicament dispenser device according to claim 41, wherein said elongate strip-form blister pack comprises (a) a base sheet in which blisters are formed to define pockets therein, each containing medicament powder; (b) a lid sheet which is sealed to the base sheet except in the region of the blisters and mechanically peelable from the base sheet to enable release of said medicament powder. 43. The medicament dispenser device according to claim 39, comprising a blister pack, wherein the medicament powder contained therein comprises both a bronchodilator and an anti-inflammatory as active medicament components thereof. 44. The medicament dispenser device according to claim 39, comprising first and second blister packs, wherein the medicament powder contained in said first blister pack comprises a bronchodilator as the active medicament component and the medicament powder contained in said second blister pack comprises an anti-inflammatory as the active medicament component. 45. The medicament dispenser device according to claim 43, wherein said bronchodilator is a beta-agonist and said anti-inflammatory is a corticosteroid. 46. The medicament dispenser device according to claim 41, wherein the at least one blister pack has a portion which is adapted in use to be separated lengthways from the at least one blister pack to open the blisters. 47. The medicament dispenser device according to claim 46, wherein the separable portion is a first portion of the at least one blister pack and the at least one blister pack further has a second portion from which the first portion is separable, the blisters being defined between the first and second portions. 48. The medicament dispenser device according to claim 47, wherein the second portion is formed with a series of recesses along its length in which the medicament powder is contained and the first portion provides a lid for each of the recesses. 49. The medicament dispenser device according to claim 46, wherein the separable portion has first and second ends which are spaced lengthways from one another and the separable portion is separable from the at least one blister pack by drawing the first end lengthways along the at least one blister pack towards the second end. 50. The medicament dispenser device according to claim 39 comprising first and second blister packs, each pack having at least one pocket each containing an inhalable medicament powder, wherein the at least one pocket of the first pack contains at least one medicament which is not in the at least one pocket of the second pack. 51. The medicament dispenser device according to claim 50, wherein the inhalable medicament powder in each pack is for treatment of respiratory disease. 52. The manifold according to claim 5, wherein essentially circular profile has a diameter of from 1 to 7 mm. 53. The manifold according to claim 12, wherein the one or more bleed holes have a cross-sectional area of from 10 to 30 mm.sup.2. 54. The manifold according to claim 14, wherein the one or more bleed holes each has a length of from 3 to 10 mm and a width of from 0.7 to 2 mm. 55. The manifold according to claim 17, wherein the spacing of the one or more bleed holes from the chamber inlet amounts to at least 20% of the length of the chamber measured from the chamber inlet to the chamber exit. 56. The manifold according to claim 54, wherein the spacing of the one or more bleed holes from the chamber inlet amounts to at least 30% of the length of the chamber measured from the chamber inlet to the chamber exit. 57. The manifold according to claim 1 wherein the chamber has only a single chamber exit. 58. The manifold according to claim 1 wherein manifold comprises a pair of curved walls for receiving the open blister pocket of each of the plural blister packs. 59. The manifold according to claim 58 wherein each curved wall defines one of the plural pairings of chimney exit and chamber inlet. 60. The manifold according to claim 15, wherein the elongate slots have a tapering profile, narrowing from a first end nearest the chamber exit to a second end nearest the chimney exits. 61. The manifold according to claim 60 wherein the bleed holes are configured and arranged so that, in use, the second portion of the airstream additionally flow around the boundary surface of the chamber forming a sheath-like blanket adjacent the boundary surface.