Claims for Patent: 8,906,887

Summary for Patent: 8,906,887

Title:	C7-fluoro substituted tetracycline compounds
Abstract:	The present invention is directed to a compound represented by Structural Formula (A): ##STR00001## or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.
Inventor(s):	Zhou; Jingye (Belmont, MA), Xiao; Xiao-Yi (San Diego, CA), Plamondon; Louis (Belmont, MA), Hunt; Diana Katharine (Cambridge, MA), Clark; Roger B. (Lexington, MA), Zahler; Robert B. (Pennington, NJ)
Assignee:	Tetraphase Pharmaceuticals, Inc. (Watertown, MA)
Application Number:	12/462,795
Patent Claims:	1. A solid pharmaceutical composition comprising a compound represented by the following structural formula: ##STR00221## or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, wherein the compound is present in an amount effective to treat bacterial infections in a range from about 0.5 milligrams to about 500 milligrams. 2. The solid pharmaceutical composition of claim 1, wherein the pharmaceutical composition is in the form of a powder, pill, tablet or capsule. 3. The solid pharmaceutical composition of claim 1, wherein the pharmaceutically acceptable carrier includes at least one member of the group consisting of a granulating agent, a lubricant, a glidant, a binder, a disintegrating agent, an inert pharmaceutical excipient and a tableting ingredient. 4. The solid pharmaceutical composition of claim 1, wherein the pharmaceutically acceptable carrier includes a binder. 5. The solid pharmaceutical composition of claim 4, wherein the binder includes at least one member selected from the group consisting of a starch, a gelatin, a natural sugar, a corn sweetener, a natural gum and a synthetic gum. 6. The solid pharmaceutical composition of claim 1, wherein the pharmaceutically acceptable carrier includes a tableting ingredient. 7. The solid pharmaceutical composition of claim 6, wherein the tableting ingredient includes at least one member of the group consisting of corn starch, lactose, sucrose, sorbitol, talc, stearic acid, magnesium stearate, dicalcium phosphate and a gum. 8. The solid pharmaceutical composition of claim 1, wherein pharmaceutical carrier includes a disintegrating agent. 9. The solid pharmaceutical composition of claim 8, wherein the disintegrating agent includes at least one member selected from the group consisting of starch, methyl cellulose, agar and bentonite. 10. The solid pharmaceutical composition of claim 1, wherein the composition is in the form of a tablet. 11. The solid pharmaceutical composition of claim 1, wherein the composition includes a disintegrating agent. 12. The solid pharmaceutical composition of claim 11, wherein the composition includes a glidant. 13. The solid pharmaceutical composition of claim 12, wherein the composition includes a lubricant. 14. The solid pharmaceutical composition of claim 13, wherein the composition includes a binder. 15. The solid pharmaceutical composition of claim 1, wherein the compound is in the form of a powder.