Claims for Patent: 9,084,765

Summary for Patent: 9,084,765

Title:	Use of amisulpride as an anti-emetic
Abstract:	Amisulpride is used in the therapy of nausea, vomiting or retches. The therapy may utilize a novel injectable formulation, in unit dosage form, comprising less than 50 mg amisulpride.
Inventor(s):	Gilbert; Julian Clive (Cambridgeshire, GB), Gristwood; Robert William (Cambridge, GB), Cooper; Nicola (Essex, GB), Fox; Gabriel (Cambridgeshire, GB)
Assignee:	Acacia Pharma Limited (Cambridgeshire, GB)
Application Number:	13/559,168
Patent Claims:	1. A method for the prevention and/or treatment of post-operative nausea and vomiting, wherein said method comprises administering amisulpride racemate at a dose of 2.5 mg to 20 mg to a subject of a surgical procedure and in need of such prevention and/or treatment. 2. The method according to claim 1, wherein the subject is also administered an emetogenic agent. 3. The method according to claim 2, wherein the emetogenic agent is an opiate. 4. The method according to claim 2, wherein the emetogenic agent is morphine. 5. The method according to claim 1, wherein the amisulpride is administered by intravenous injection. 6. The method according to claim 1, wherein the amisulpride is administered by intramuscular injection. 7. The method according to claim 1, wherein the amisulpride is administered by subcutaneous injection. 8. The method according to claim 1, wherein the subject is a human. 9. The method according to claim 1, wherein the amisulpride is in the form of an acceptable pharmaceutical salt. 10. The method according to claim 1, wherein the amisulpride is administered in combination with another anti-emetic drug. 11. The method according to claim 10, wherein the another anti-emetic drug is a 5HT3 antagonist. 12. The method according to claim 11, wherein the 5HT3 antagonist is ondansetron. 13. The method according to claim 1, wherein the amisulpride is administered at a dose of 2.5 mg. 14. The method according to claim 1, wherein the amisulpride is administered at a dose of 5 mg. 15. The method according to claim 1, wherein the amisulpride is administered at a dose of 20 mg. 16. The method according to claim 1, wherein the amisulpride is administered orally. 17. The method according to claim 1, wherein the subject has received an anesthetic. 18. The method according to claim 1, wherein the surgical procedure is chosen from procedures of the eye or ear, laparoscopic cholecystectomy, hysterectomy, breast surgery, abdominal surgery, and gynecological surgery. 19. A method for the prevention and/or treatment of post-operative nausea and vomiting, wherein said method comprises administering amisulpride racemate at a dose of 1 mg to 20 mg to a subject of a surgical procedure and in need of such prevention and/or treatment. 20. The method according to claim 19, wherein the subject is also administered an emetogenic agent. 21. The method according to claim 20, wherein the emetogenic agent is an opiate. 22. The method according to claim 20, wherein the emetogenic agent is morphine. 23. The method according to claim 19, wherein the amisulpride is administered by intravenous injection. 24. The method according to claim 19, wherein the amisulpride is administered by intramuscular injection. 25. The method according to claim 19, wherein the amisulpride is administered by subcutaneous injection. 26. The method according to claim 19, wherein the subject is a human. 27. The method according to claim 19, wherein the amisulpride is in the form of an acceptable pharmaceutical salt. 28. The method according to claim 19, wherein the amisulpride is administered in combination with another anti-emetic drug. 29. The method according to claim 28, wherein the another anti-emetic drug is a 5HT3 antagonist. 30. The method according to claim 29, wherein the 5HT3 antagonist is ondansetron. 31. The method according to claim 19, wherein the amisulpride is administered orally. 32. The method according to claim 19, wherein the subject has received an anesthetic. 33. The method according to claim 19, wherein the surgical procedure is chosen from procedures of the eye or ear, laparoscopic cholecystectomy, hysterectomy, breast surgery, abdominal surgery, and gynecological surgery.