Claims for Patent: 9,867,863

Summary for Patent: 9,867,863

Title:	Method of treating low blood pressure
Abstract:	A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.
Inventor(s):	Chawla; Lakhmir (McLean, VA)
Assignee:	The George Washington University a Congressionally Chartered Not-for-Profit Corporation (Washington, DC)
Application Number:	15/380,574
Patent Claims:	1. A method of treating a human patient suffering from refractory hypotension, comprising administering angiotensin II to the patient at a rate of about 5 ng/kg/min to about 10 ng/kg/min while the patient is receiving a vasopressor, wherein the vasopressor is vasopressin or a catecholamine. 2. The method of claim 1, wherein the Angiotensin II is administered to the patient over a period of from about 1 hour to about 7 hours. 3. The method of claim 1, wherein the Angiotensin II is administered to the patient over a period of from about 2 hours to about 6 hours. 4. The method of claim 1, wherein the Angiotensin II is administered to the patient over a period of from about 3 hours to about 5 hours. 5. The method of claim 1, wherein the vasopressor is vasopressin. 6. The method of claim 1, wherein the vasopressor is a catecholamine. 7. The method of claim 6, wherein the catecholamine is norepinephrine. 8. The method of claim 7, wherein the norepinephrine is administered to the patient at a rate of >15 mcg/min. 9. The method of claim 1, wherein the rate of administration is about 5 ng/kg/min. 10. The method of claim 9, wherein the Angiotensin II is administered to the patient over a period of from about 1 hour to about 7 hours. 11. The method of claim 9, wherein the Angiotensin II is administered to the patient over a period of from about 2 hours to about 6 hours. 12. The method of claim 9, wherein the Angiotensin II is administered to the patient over a period of from about 3 hours to about 5 hours. 13. The method of claim 9, wherein the vasopressor is vasopressin. 14. The method of claim 9, wherein the vasopressor is a catecholamine. 15. The method of claim 1, wherein the rate of administration is about 10 ng/kg/min. 16. The method of claim 15, wherein the Angiotensin II is administered to the patient over a period of from about 1 hour to about 7 hours. 17. The method of claim 15, wherein the Angiotensin II is administered to the patient over a period of from about 2 hours to about 6 hours. 18. The method of claim 15, wherein the Angiotensin II is administered to the patient over a period of from about 3 hours to about 5 hours. 19. The method of claim 15, wherein the vasopressor is vasopressin. 20. The method of claim 15, wherein the vasopressor is a catecholamine. 21. A method of treating a human patient suffering from refractory hypotension, comprising administering angiotensin II to the patient at a rate of about 5 ng/kg/min to about 20 ng/kg/min while the patient is receiving a vasopressor, wherein the vasopressor is vasopressin or a catecholamine. 22. The method of claim 21, wherein the Angiotensin II is administered to the patient over a period of from about 1 hour to about 7 hours. 23. The method of claim 21, wherein the Angiotensin II is administered to the patient over a period of from about 2 hours to about 6 hours. 24. The method of claim 21, wherein the Angiotensin II is administered to the patient over a period of from about 3 hours to about 5 hours. 25. The method of claim 21, wherein the vasopressor is vasopressin. 26. The method of claim 21, wherein the vasopressor is a catecholamine. 27. The method of claim 26, wherein the catecholamine is norepinephrine. 28. The method of claim 27, wherein the norepinephrine is administered to the patient at a rate of >15 mcg/min.