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Last Updated: November 2, 2024

Details for Patent: 10,131,907


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Summary for Patent: 10,131,907
Title:Glycoconjugates of RNA interference agents
Abstract: The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications.
Inventor(s): Forst; Andrea (Bayreuth, DE), Hadwiger; Philipp (Kulmbach, DE), Vornlocher; Hans-Peter (Bayreuth, DE)
Assignee: ALNYLAM PHARMACEUTICALS, INC. (Cambridge, MA)
Application Number:14/500,356
Patent Claim Types:
see list of patent claims
Use; Composition; Compound;

Drugs Protected by US Patent 10,131,907

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Alnylam Pharms Inc AMVUTTRA vutrisiran sodium SOLUTION;SUBCUTANEOUS 215515-001 Jun 13, 2022 RX Yes Yes ⤷  Sign Up ⤷  Sign Up Y Y AMVUTTRA IS INDICATED FOR THE TREATMENT OF THE POLYNEUROPATHY OF HEREDITARY TRANSTHYRETIN-MEDIATED AMYLOIDOSIS IN ADULTS ⤷  Sign Up
Alnylam Pharms Inc GIVLAARI givosiran sodium SOLUTION;SUBCUTANEOUS 212194-001 Nov 20, 2019 RX Yes Yes ⤷  Sign Up ⤷  Sign Up Y Y TREATMENT OF ACUTE HEPATIC PORPHYRIA ⤷  Sign Up
Novartis LEQVIO inclisiran sodium SOLUTION;SUBCUTANEOUS 214012-001 Dec 22, 2021 RX Yes Yes ⤷  Sign Up ⤷  Sign Up Y Y AS AN ADJUNCT TO DIET AND STATIN THERAPY FOR THE TREATMENT OF ADULTS WITH PRIMARY HYPERLIPIDEMIA, INCLUDING HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HEFH), BY INHIBITING EXPRESSION OF THE PCSK9 GENE ⤷  Sign Up
Alnylam Pharms Inc OXLUMO lumasiran sodium SOLUTION;SUBCUTANEOUS 214103-001 Nov 23, 2020 RX Yes Yes ⤷  Sign Up ⤷  Sign Up Y Y TREATMENT OF PRIMARY HYPEROXALURIA TYPE 1 (PH1) ⤷  Sign Up
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 10,131,907

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 2008242583 ⤷  Sign Up
Canada 2685127 ⤷  Sign Up
World Intellectual Property Organization (WIPO) 2008131419 ⤷  Sign Up
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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