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Last Updated: December 22, 2024

Details for Patent: 3,987,052


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Summary for Patent: 3,987,052
Title: 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
Abstract:6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines of the formula (IV): ##SPC1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, phenyl, benzyl and -COOR' in which R' is alkyl of 1 to 4 carbon atoms, inclusive; wherein R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms, inclusive; and wherein R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms, inclusive, halogen, nitro, cyano, trifluoromethyl, and alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoylamino and dialkylamino in which the carbon chain moieties are of 1 to 3 carbon atoms, inclusive, are produced by condensing a 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione of the formula (I): ##SPC2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined as above, with an organic acid hydrazide of the formula: ##EQU1## wherein R is defined as above. The new products of formula IV including their pharmacologically acceptable acid addition salts are useful as sedatives, tranquilizers and muscle relaxants in mammals and birds.
Inventor(s): Hester, Jr.; Jackson B. (Kalamazoo, MI)
Assignee: The Upjohn Company (Kalamazoo, MI)
Application Number:04/872,394
Patent Claim Types:
see list of patent claims
Compound;
Patent landscape, scope, and claims:

United States Patent 3,987,052: A Detailed Analysis of Scope, Claims, and Patent Landscape

Introduction

United States Patent 3,987,052, titled "6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines," is a significant patent in the field of organic chemistry, particularly concerning the synthesis and application of novel benzodiazepine compounds. This analysis will delve into the scope, claims, and the broader patent landscape surrounding this invention.

Background and Field of the Invention

The patent, filed as a continuation-in-part of application Ser. No. 807,933, focuses on new organic compounds known as 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines. These compounds are part of the benzodiazepine family, which is well-known for its therapeutic applications, including anxiolytic, sedative, and anticonvulsant properties[4].

Scope of the Patent

The scope of the patent is defined by the claims, which outline the specific inventions and processes covered. Here, the patent covers:

  • Novel Compounds: The invention is directed towards new 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines, which are characterized by their unique chemical structure.
  • Process of Production: The patent also describes a process for the production of these compounds, including the synthesis steps and the various substituents that can be used to modify the chemical structure[4].

Claims Analysis

The patent includes several claims that define the boundaries of the invention:

  • Independent Claims: These claims are crucial as they define the core of the invention. For example, Claim 1 describes the general structure of the 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines, including the possible substituents.
  • Dependent Claims: These claims further specify the invention by detailing specific embodiments or variations of the compounds and processes described in the independent claims.

Patent Claims and Scope Metrics

The scope of patent claims can be measured using metrics such as independent claim length and independent claim count. Research suggests that narrower claims, as measured by these metrics, are associated with a higher probability of grant and a shorter examination process. This patent, with its detailed and specific claims, aligns with the trend of narrower claims being more favorable during the examination process[3].

Patent Landscape

Related Patents and Prior Art

The patent landscape surrounding US 3,987,052 includes a plethora of related patents and prior art in the field of benzodiazepines. For instance, other patents like US 4,130,709 A and US 4,280,957 A, listed in the references cited section of the patent, indicate a rich history of research and development in this area[1].

Regulatory and Extension Considerations

Patents in the pharmaceutical and chemical fields often undergo regulatory reviews that can impact their term. Under 35 U.S.C. 156, patents can be extended if they are subject to certain regulatory reviews by the FDA or the Department of Agriculture. While US 3,987,052 does not appear to have been extended under this section, understanding these regulations is crucial for managing patent portfolios in this field[2].

Industry Impact and Applications

The compounds described in US 3,987,052 have potential therapeutic applications. Benzodiazepines are widely used in medicine for their anxiolytic, sedative, and anticonvulsant properties. The novel compounds and synthesis processes outlined in this patent could contribute to the development of new drugs or improve existing ones.

Litigation and Patent Quality Concerns

The quality and scope of patent claims, especially in the pharmaceutical and chemical sectors, are often subjects of debate. Broad or unclear claims can lead to increased licensing and litigation costs, potentially hindering innovation. The specific and detailed claims in US 3,987,052 suggest a careful approach to defining the invention, which is in line with best practices for maintaining patent quality[3].

Expert Insights and Statistics

Industry experts often emphasize the importance of clear and narrow patent claims. For example, a Federal Trade Commission (FTC) report highlighted concerns about broad and unclear claims in software and internet patents, which can impede innovation. In contrast, patents like US 3,987,052, with their well-defined claims, contribute positively to the patent landscape[3].

"Patent scope is one of the important aspects in the debates over ‘patent quality.’ The purported decrease in patent quality over the past decade or two has supposedly led to granting patents of increased breadth (or ‘overly broad’ patents), decreased clarity, and questionable validity." - Alan C. Marco, U.S. Patent and Trademark Office[3]

Key Takeaways

  • Specific Claims: The patent includes detailed and specific claims that define the novel compounds and their synthesis processes.
  • Regulatory Considerations: Understanding regulatory reviews and potential patent term extensions is crucial for managing patents in this field.
  • Industry Impact: The compounds have significant therapeutic applications and contribute to the development of new drugs.
  • Patent Quality: The patent's clear and narrow claims align with best practices for maintaining patent quality.

FAQs

Q: What is the main focus of United States Patent 3,987,052?

A: The patent focuses on new organic compounds known as 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines and the process for their production.

Q: What are the therapeutic applications of the compounds described in the patent?

A: The compounds have potential therapeutic applications as anxiolytics, sedatives, and anticonvulsants.

Q: How are the claims in this patent structured?

A: The patent includes independent claims that define the core of the invention and dependent claims that specify further embodiments or variations.

Q: What metrics can be used to measure the scope of patent claims?

A: Metrics such as independent claim length and independent claim count can be used to measure the scope of patent claims.

Q: Why is patent quality important in the context of this patent?

A: Patent quality, including clear and narrow claims, is important to avoid licensing and litigation costs and to maintain incentives for innovation.

Sources Cited

  1. United States Patent and Trademark Office, "US11241414.pdf" - Google Patents.
  2. United States Patent and Trademark Office, "Extension Under 35 U.S.C. 156(e)(1)" - OG Date: 29 July 2003.
  3. Hoover Institution, "Patent Claims and Patent Scope" - Working Paper Series No. 16001.
  4. Google Patents, "US3987052A - 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines".

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Drugs Protected by US Patent 3,987,052

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 3,987,052

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 490626 ⤷  Subscribe
Australia 491139 ⤷  Subscribe
Belgium 747493 ⤷  Subscribe
Belgium 779988 ⤷  Subscribe
Brazil 7017488 ⤷  Subscribe
Switzerland 535788 ⤷  Subscribe
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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