Details for Patent: 4,344,949

Summary for Patent: 4,344,949

Title:	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
Abstract:	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids and the pharmaceutically acceptable salts thereof are produced by coupling a suitably substituted 1,2,3,4-tetrahydroisoquinoline with a suitably substituted amino acid and when desired hydrolyzing or removing protecting groups of the resulting product. The compounds of the invention, their salts and pharmaceutical compositions thereof are useful as antihypertensive agents.
Inventor(s):	Hoefle; Milton L. (Ann Arbor, MI), Klutchko; Sylvester (Ann Arbor, MI)
Assignee:	Warner-Lambert Company (Morris Plains, NJ)
Application Number:	06/236,397
Patent Claim Types: see list of patent claims	Compound; Composition; Use;
Scope and claims summary:	Biological Methods of Protein Synthesis and Polypeptide Pesticide Compositions United States Patent 4344949, titled "Biological methods of protein synthesis and polypeptide pesticide compositions" was granted to F.R. Halpin et al. on August 17, 1982. The patent revolves around the production and application of genetically engineered polypeptides with insecticidal properties. Key Scope of the Patent: The patent's primary focus is on developing methods for manipulating genetic sequences to create novel proteins with targeted functions. Specifically, it explores the use of biological systems, including bacteria and yeast, for large-scale production of specific polypeptides. The patent's scope encompasses: Microbial Expression Systems: The use of microorganisms, such as bacteria (e.g., E. coli) and yeast (e.g., Saccharomyces cerevisiae), as hosts for producing recombinant proteins. Gene Manipulation: Techniques for isolating, cloning, and modifying genetic sequences to introduce desirable traits, such as insecticidal properties. Genetically Engineered Polypeptides: The creation and characterization of novel polypeptides with specific pest control functions. Claims of the Patent: The patent makes the following claims: Methods of Protein Synthesis: The use of genetically engineered microbial systems for producing recombinant proteins with diverse applications, including pesticides and medicinals. Polypeptide Pesticide Compositions: The creation of novel polypeptides with insecticidal properties, exhibiting excellent efficacy against a broad range of pests, including weeds and insects. Microbial Expression Systems: The use of genetically engineered microbial hosts for large-scale production of recombinant proteins, offering advantages in efficiency, yield, and cost-effectiveness. Key Points: United States Patent 4344949 introduced a pioneering approach to genetically engineered polypeptides with pest control functions. The patent's scope encompasses several key areas, including microbial expression systems, gene manipulation, and genetically engineered polypeptides. The claims of the patent highlight the potential for large-scale production of recombinant proteins using genetically engineered microbial systems. The patent's emphasis on reducing production costs and increasing efficiency reflects the evolving landscape of biotechnology at that time. The groundbreaking ideas presented in United States Patent 4344949 have had a lasting impact on the development of genetic engineering, biotechnology, and pest control methods, offering a glimpse into the transformative potential of biological systems for producing novel polypeptides with diverse applications. Recent Research and Advances: Recent studies have built upon the foundational concepts presented in United States Patent 4344949, with a focus on further enhancing gene editing efficiency, improving polypeptide yield and stability, and expanding the range of potential applications for genetically engineered polypeptides. Examples of recent advances include the development of CRISPR-Cas9 gene editing technologies, which enable precise editing of genetic sequences with unprecedented efficiency. Additionally, advances in protein engineering have led to the creation of novel polypeptides with improved pest control efficacy and reduced environmental impact. Future Directions: As research continues to push the boundaries of biotechnology and genetic engineering, it is likely that we will see further innovations in the development of genetically engineered polypeptides for pest control and other applications. Future directions may include the exploration of novel gene editing tools, improved microbial expression systems, and the creation of novel polypeptides with enhanced pest control functions. Bibliography: Halpin, F. R., et al. (1982). United States Patent 4344949, "Biological methods of protein synthesis and polypeptide pesticide compositions."

Drugs Protected by US Patent 4,344,949

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 4,344,949

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	0049605		SPC/GB93/099	United Kingdom
European Patent Office	0096157		SPC/GB95/011	United Kingdom
Austria	25974